Journal
NUTRIENTS
Volume 14, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/nu14102075
Keywords
overweight; obesity; macrosomia; triglyceride; gestational diabetes mellitus; mediation analysis
Categories
Funding
- National Natural Science Foundation Program of China [82073653, 81803313]
- Hunan Provincial Key Research and Development Program [2018SK2063, 2018SK2062]
- Hunan Provincial Science and Technology Talent Support Project [2020TJ-N07]
- Natural Science Foundation of Hunan Province [2018JJ2551]
- Open Project from NHC Key Laboratory of Birth Defect for Research and Prevention [KF2020006]
- China Postdoctoral Science Foundation [2020M682644]
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This study aimed to investigate the relationship between maternal pre-pregnancy overweight/obesity, high maternal triglyceride levels, and the risk of macrosomia. The results showed that overweight/obesity had a partially mediated effect on macrosomia through high triglyceride levels, with a mediation proportion of 11.1% and 3.8%, respectively.
This study aimed at examining the risk of macrosomia, in relation to maternal pre-pregnancy overweight/obesity mediated via high maternal triglyceride (mTG) levels. In this prospective study, 24,730 singleton term non-diabetic pregnancies were finally included. Serum mTG levels were measured using fasting blood samples that were collected after 28 weeks of gestation. High mTG levels were defined as values >= the 90th percentile. The outcome of interest was macrosomia (>= 4000 g). Log-binomial regression was used to assess the mediation path between overweight/obesity, high mTG levels, and macrosomia. The mediation analysis found a total effect of overweight on macrosomia of 0.006 (95% CI, 0.001-0.010), including a direct effect of 0.005 (95% CI, 0.001, 0.009) and indirect effect of 0.001 (95% CI, 0.000-0.001), with an estimated proportion of 11.1% mediated by high mTG levels. Additionally, we also found a total effect of obesity on macrosomia of 0.026 (95% CI, 0.018-0.036), including a direct effect of 0.025 (95% CI, 0.017-0.036) and indirect effect of 0.001 (95% CI, 0.000-0.001), with an estimated proportion of 3.8% mediated by high mTG levels. In conclusion, non-diabetic women with overweight or obesity had an increased risk of macrosomia, and this positive association was partly mediated by high mTG levels.
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