Journal
NUTRIENTS
Volume 14, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/nu14061169
Keywords
MTHFR; folate; vitamin B-12; one-carbon metabolism; gestational diabetes mellitus
Categories
Funding
- Fundamental Research Funds for Higher Education of Tianjin Municipal Education Commission [2020ZD14]
- Tianjin Xiqing Hospital Science Foundation [XQYYKLT202002, XQYYKLT201902]
- National Natural Science Foundation of China [81874262]
- National Key Research and Development Program of China [2017YFC0211605]
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This study found that higher folate concentrations were associated with increased risk of GDM, while higher B-12 concentrations were associated with reduced risk. Pregnancies with the MTHFR rs1801131 TT genotype were more susceptible to OCM nutrient-related GDM.
Circumstantial evidence links one-carbon metabolism (OCM) related nutrients, such as folate and vitamin B-12, with gestational diabetes mellitus (GDM). However, few studies have evaluated the combined effects of these nutrients with OCM related gene polymorphisms on GDM. This study investigated whether OCM related genetic variants modified the associations of folate and B-12 with GDM. Logistic regression was used to estimate odds ratios (ORs) for OCM related nutrients and single nucleotide polymorphisms (SNPs) in genes encoding main OCM related enzymes (MTHFR, MTR, and MTRR) on GDM. Higher folate concentrations were associated with increased GDM risk (OR: 1.59; 95% CI: 1.22, 2.13). However, higher B-12 concentrations were associated with reduced GDM risk (OR: 0.76; 95% CI: 0.65, 0.92). Pregnancies with MTHFR rs1801131 G alleles had a significantly lower risk of GDM than pregnancies with T alleles (OR: 0.65; 95% CI: 0.47, 0.91) under the dominant model. The genotype-stratified analysis revealed the association between folate and GDM (OR: 1.66, 95% CI: 1.20, 2.30) or B-12 and GDM (OR: 0.80, 95% CI: 0.65, 0.98) was more evident in pregnancies with TT genotype. Higher folate and lower B-12 are associated with GDM. Pregnancies with MTHFR rs1801131 TT genotype are more susceptible to OCM nutrient-related GDM.
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