Journal
NUTRIENTS
Volume 14, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/nu14102082
Keywords
chronic kidney disease; eGFR; nutritional vitamins; PTGS1; precision nutrition
Categories
Funding
- Ministry of Education, Culture, Sport, Science, and Technology (MEXT) [19H03882]
- Grants-in-Aid for Scientific Research [19H03882] Funding Source: KAKEN
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This study aimed to investigate the interaction between dietary vitamin intake and the rs883484 genotype in the development of CKD. The results showed that higher intake of niacin, alpha-tocopherol, and vitamin C were independently associated with a lower tendency of CKD in individuals with the minor homozygotes of the rs883484 gene variant. This suggests the importance of dietary vitamin intake in preventing CKD in middle-aged to older-aged Japanese individuals with this specific gene variant.
Chronic kidney disease (CKD) patients have been advised to take vitamins; however, the effects have been controversial. The individual differences in developing CKD might involve genetic variants of inflammation, including variant rs883484 located upstream of the prostaglandin-endoperoxide synthase 1 (PTGS1) gene. We aimed to identify whether the 12 dietary vitamin intake interacts with genotypes of the rs883484 on developing CKD. The population-based, cross-sectional study had 684 Japanese participants (>= 40 years old). The study used a validated, brief, self-administered diet history questionnaire to estimate the intake of the dietary vitamins. CKD was defined as estimated glomerular filtration < 60 mL/min/1.73 m(2). The study participants had an average age of 62.1 +/- 10.8 years with 15.4% minor homozygotes of rs883484, and 114 subjects had CKD. In the fully adjusted model, the higher intake of vitamins, namely niacin (odds ratio (OR) = 0.74, 95% confidence interval (CI): 0.57-0.96, p = 0.024), alpha-tocopherol (OR = 0.49, 95% CI: 0.26-0.95, p = 0.034), and vitamin C (OR = 0.97, 95% CI: 0.95-1.00, p = 0.037), was independently associated with lower CKD tendency in the minor homozygotes of rs883484. The results suggested the importance of dietary vitamin intake in the prevention of CKD in middle-aged to older-aged Japanese with minor homozygous of rs883484 gene variant.
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