Journal
NEUROSCIENCE BULLETIN
Volume 38, Issue 11, Pages 1383-1396Publisher
SPRINGER
DOI: 10.1007/s12264-022-00860-7
Keywords
Viral tracing; Neural circuit; Anterograde; Retrograde; Transsynaptic
Categories
Funding
- National Key Research and Development Program of China [2021ZD0202700, 2021ZD0202703]
- National Natural Science Foundation of China [32070974]
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The anatomical organization of neural circuits is essential for understanding brain functions, and viral tools have become widely used for tracing circuit architecture. This review introduces the categories and applications of viral tools in circuit tracing, as well as discussing advancements and future innovations in viral tracing.
Neurons are highly interwoven to form intricate neural circuits that underlie the diverse functions of the brain. Dissecting the anatomical organization of neural circuits is key to deciphering how the brain processes information, produces thoughts, and instructs behaviors. Over the past decades, recombinant viral vectors have become the most commonly used tracing tools to define circuit architecture. In this review, we introduce the current categories of viral tools and their proper application in circuit tracing. We further discuss some advances in viral tracing strategy and prospective innovations of viral tools for future study.
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