Journal
MATERIALS
Volume 15, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ma15093132
Keywords
corrosion resistance; magnesium alloy; bioresorbable stent; parylene C; surface coating
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Funding
- New Energy and Industrial Technology Development Organization (NEDO) [P14033-28J1011]
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The study found that coating the magnesium alloy stent with parylene C can improve its corrosion resistance, ensuring its stability in cell culture medium. This provides new possibilities for the development of bioresorbable magnesium alloy stents in clinical applications.
Magnesium (Mg) alloy has attracted significant attention as a bioresorbable scaffold for use as a next-generation stent because of its mechanical properties and biocompatibility. However, Mg alloy quickly degrades in the physiological environment. In this study, we investigated whether applying a parylene C coating can improve the corrosion resistance of a Mg alloy stent, which is made of 'Original ZM10', free of aluminum and rare earth elements. The coating exhibited a smooth surface with no large cracks, even after balloon expansion of the stent, and improved the corrosion resistance of the stent in cell culture medium. In particular, the parylene C coating of a hydrofluoric acid-treated Mg alloy stent led to excellent corrosion resistance. In addition, the parylene C coating did not affect a polymer layer consisting of poly(epsilon-caprolactone) and poly(D,L-lactic acid) applied as an additional coating for the drug release to suppress restenosis. Parylene C is a promising surface coating for bioresorbable Mg alloy stents for clinical applications.
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