Journal
MATERIALS
Volume 15, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ma15093085
Keywords
pyridine; hydrazone; synthesis; antimicrobial activity; tuberculostatic activity; X-ray; DFT calculations
Categories
Funding
- National Science Centre (Cracow, Poland) [2017/25/B/NZ7/00124]
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In this study, four novel methyl 4-phenylpicolinoimidate derivatives of hydrazone were synthesized and evaluated for their antimicrobial activity. Compound 3b exhibited significant activity against Gram-positive bacteria, while derivatives 3a and 4a showed higher activity against tuberculosis. These findings provide valuable insights for the development of antimicrobial and anti-tuberculosis drugs.
Four novel methyl 4-phenylpicolinoimidate derivatives of hydrazone have been synthesized and evaluated for their antimicrobial activity, including tuberculostatic activity. The compounds obtained are condensates of hydrazonamide or hydrazide with 5-nitro-2-furaldehyde or 5-nitro-2-thiophenecarboxaldehyde. The antimicrobial activity of the tested compounds varied. Compound 3b exhibited significant activity against the tested Gram-positive bacteria (7.8-250 mu g/mL). The results of structural tests revealed that the compound is the only one obtained in the form of a Z isomer. Tuberculostatic activity tests showed higher activity of derivatives 3a and 4a containing nitrofuran systems (MICs 3.1-12.5 mu g/mL). This research allowed us to identify hydrazone 3b as a starting point for further optimization in the search for antimicrobial drugs. Likewise, compound 4a appears to be a good guiding structure for use in future research on new anti-tuberculosis drugs.
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