Journal
CANCER LETTERS
Volume 356, Issue 1, Pages 17-21Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.09.009
Keywords
Non-targeted effects; Ionizing radiation; Cell-cell communication
Categories
Funding
- Battelle Memorial Institute, Pacific Northwest Division [DE-AC05-76RL0 1830]
- US Department of Energy (DOE), Office of Biological and Environmental Research (OBER) Low Dose Radiation Science Program
Ask authors/readers for more resources
Not-targeted effects represent a paradigm shift from the DNA centric view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-targeted effects associated with radiation exposure might play a significant role. Here definitions of non-targeted effects are presented, the potential mechanisms for the communication of signals and signaling networks from irradiated cells/tissues are proposed, and the various effects of this intra- and intercellular signaling are described. We conclude with speculation on how these observations might lead to and impact long-term human health outcomes. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available