Journal
JOURNAL OF OVARIAN RESEARCH
Volume 15, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13048-022-00981-7
Keywords
Ovarian cancer; miR-600; KLF9; Stemness; Metastasis
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Funding
- Natural Fund Guidance Program of Liaoning Province [2019-ZD-1072]
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Previous studies have shown that miR-600 plays a role in the pathogenesis of ovarian cancer. This study further demonstrates that miR-600 promotes stemness, proliferation, and metastasis of ovarian cancer cells by directly downregulating KLF9 expression.
Previous studies have revealed that miRNAs participate in the pathogenesis of ovarian cancer; however, whether miR-600 is also involved remains unclear. In this study, we aimed to investigated the role of miR-600 in ovarian cancer progression. Here, miR-600 expression was significantly upregulated in ovarian cancer tissues and stem cells. Functional studies showed that miR-600 promoted ovarian cancer cell stemness, proliferation and metastasis. Mechanistic studies revealed that Kruppel like factor 9 (KLF9) was indicated as the target of miR-600. The luciferase reporter assay suggested that miR-600 directly bound to the 3 '-untranslated region of KLF9. Additionally, miR-600 expression was negatively associated with KLF9 expression in human ovarian cancer tissues. Si-KLF9 partially abolished the discrepancy of self-renewal, growth and metastasis capacity between miR-600 knockdown ovarian cancer cells and control cells. In conclusion, our results suggest that miR-600 promotes ovarian cancer cell stemness, proliferation and metastasis via directly downregulating KLF9, and impairing miR-600 levels may be a new treatment strategy for ovarian cancer in the future.
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