4.6 Article

High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer

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Summary: Receptor-interacting protein kinases (RIPKs) are key regulators of inflammatory signaling and cell death pathways triggered by innate immune receptors, with RIPK2 playing a crucial role in regulating intestinal immunity and inflammation. The modification of RIPK2 by nondegradative ubiquitin chains, governed by XIAP and other ligases, is essential for NOD1/2 signaling, providing a potential target for modulating immune responses. Ongoing efforts are focused on targeting RIPK2 in inflammatory bowel disease and other immune-related disorders.

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