4.0 Review

Oral side effects of locally delivered nicotine replacement therapy: A meta-analysis of randomized controlled trials

Journal

INTERNATIONAL JOURNAL OF DENTAL HYGIENE
Volume 21, Issue 1, Pages 3-17

Publisher

WILEY
DOI: 10.1111/idh.12594

Keywords

adverse drug reaction; nicotine withdrawal; oral effects; quit smoking; tobacco control

Ask authors/readers for more resources

This meta-analysis aimed to evaluate the evidence of oral side effects caused by nicotine replacement therapy (NRT), and found that the number of patients experiencing oral discomfort significantly increased with the use of NRT. Therefore, it is crucial for patients using NRT to have regular dental visits and check their oral mucosa.
Background Nicotine replacement therapy is the first choice pharmacotherapy for smoking cessation. Oral side effects caused due to NRT lead to discontinuation of treatment. The objective of this meta-analysis was to look for the certainty of evidence on the number of patients that reported oral side effects due to the use of NRT. Method Eligible studies were selected and data extraction was carried out independently into a pre-tested data extraction form. Risk of bias was assessed using Cochrane Tool. The heterogeneity between the studies was assessed using Chi-square and I2 tests. Mean difference and Odds ratio at 95% confidence interval were the effect estimates. GRADE working group approach was used to assess the quality of evidence. Results Twenty-eight studies were included with moderate to low risk of bias. The pooled estimates revealed a statistically significant number of patients developed mouth or throat irritation (2.54 [1.23, 5.25]), or oral soreness (2.22 [1.40, 3.55]) or gastric reflux or vomiting (1.97 [1.34, 2.90]) due to NRT. Conclusion It is important to understand that significant implications are caused due to NRT, on oral health. All patients on NRT must adhere to their regular dentist visits and must check their oral mucosa before initiating NRT.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.0
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available