Journal
CANCER LETTERS
Volume 356, Issue 2, Pages 211-216Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.02.019
Keywords
Acetate; Acetyl CoA; Fatty acid; Positron emission tomography; Metabolism
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Funding
- JSPS KAKENHI [19790864, 23791403]
- Grants-in-Aid for Scientific Research [19790864, 23791403] Funding Source: KAKEN
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Understanding cancer-specific metabolism is important for identifying novel targets for cancer diagnosis and therapy. Induced acetate/acetyl CoA metabolism is a notable feature that is related to fatty acid synthesis supporting tumor growth. In this review, we focused on the recent findings related to cancer acetate/acetyl CoA metabolism. We also introduce [1-C-11]acetate positron emission tomography (PET), which is a useful tool to visualize up-regulation of acetate/acetyl CoA metabolism in cancer, and discuss the utility of [1:C-11]acetate PET in cancer diagnosis and its application to personalized medicine. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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