Journal
CANCER DISCOVERY
Volume 12, Issue 5, Pages 1195-1198Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-22-0076
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Funding
- NIH [R35-CA209919, RM1-HG007735]
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Extrachromosomal DNA circles (ecDNA) serve as a common mechanism for oncogene amplification and are associated with worse clinical outcomes. Recent discoveries of ecDNA hubs in the nucleus reveal unique features that contribute to higher oncogene expression and rapid tumor evolution.
Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs-local congregations of ecDNAs in the nucleus-highlight unique features of ecDNA biology that may contribute to higher oncogene expression and rapid tumor evolution.
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