Journal
ACS CATALYSIS
Volume 12, Issue 9, Pages 5510-5516Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.2c00064
Keywords
chiral phosphoric acid; carbene; visible light; 1,4-dicarbonyl compounds; diazoesters
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Funding
- National Natural Science Foundation of China [21971094]
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We have developed an efficient visible-light-mediated formal carbene insertion reaction using 1,3-diketones and diazoesters for the synthesis of enantioenriched 1,4-dicarbonyl compounds with a quaternary carbon center. By combining visible light and a Bronsted acid catalyst, we achieved chiral 1,4-dicarbonyl compounds in good yields with high enantioselectivities through a photochemical carbene transfer protocol.
We developed an efficient visible-light-mediated formal carbene insertion reaction of 1,3-diketones with diazoesters for the construction of enantioenriched 1,4-dicarbonyl compounds with a quaternary carbon center. Combining visible light and a Bronsted acid catalyst, chiral 1,4-dicarbonyl compounds were achieved in good yields with high enantioselectivities by a photochemical carbene transfer protocol.
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