Journal
NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-30675-z
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Funding
- National Human Genome Research Institute [1K08HG010155, 1U01HG011719]
- Massachusetts General Hospital
- Merkin Institute Fellowship from the Broad Institute of MIT and Harvard
- Bayer
- Eric and Wendy Schmidt Center
- IBM Research
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Polygenic scores can be used to identify individuals with high disease risk based on inherited DNA variations. This has the potential to enhance clinical trials by targeting individuals with higher risk for disease or increased likelihood of benefiting from treatment.
Polygenic scores can identify individuals with high disease risk based on inborn DNA variation. We explore their potential to enrich clinical trials by identifying individuals based on higher risk of disease ('prognostic enrichment'), or increased probability of benefit ('predictive enrichment').
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