Journal
NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-30051-x
Keywords
-
Categories
Funding
- Schmidt Science
- Rhodes Trust
- National Institute of General Medical Science [3U24GM132013-02S2]
- National Institutes of Health/National Institute of General Medical Sciences [R35GM138361-02]
- Chan Zuckerberg Biohub Investigator program
- ZSFG Department of Medicine and Division of HIV, ID, and Global Medicine
- MIDAS Coordination Center COVID-19 Urgent Grant Program [MIDASNI2020-5]
Ask authors/readers for more resources
This study analyzes data from a serological surveillance platform in San Francisco and finds significant variation in infection and vaccination history by race/ethnicity and socioeconomic status.
As SARS-CoV-2 continues to spread and vaccines are rolled-out, the double burden of disparities in exposure and vaccination intersect to determine patterns of infection, immunity, and mortality. Serology provides a unique opportunity to measure prior infection and vaccination simultaneously. Leveraging algorithmically-selected residual sera from two hospital networks in the city of San Francisco, cross-sectional samples from 1,014 individuals from February 4-17, 2021 were each tested on two assays (Ortho Clinical Diagnostics VITROS Anti-SARS-CoV-2 and Roche Elecsys Anti-SARS-CoV-2), capturing the first year of the epidemic and early roll-out of vaccination. We estimated, using Bayesian estimation of infection and vaccination, that infection risk of Hispanic/Latinx residents was five times greater than of White residents aged 18-64 (95% Credible Interval (CrI): 3.2-10.3), and that White residents over 65 were twice as likely to be vaccinated as Black/African American residents (95% CrI: 1.1-4.6). We found that socioeconomically-deprived zipcodes had higher infection probabilities and lower vaccination coverage than wealthier zipcodes. While vaccination has created a 'light at the end of the tunnel' for this pandemic, ongoing challenges in achieving and maintaining equity must also be considered. Continued monitoring of SARS-CoV-2 at the population level is important for identifying at-risk groups. Here the authors analyse data from a serological surveillance platform in San Francisco and find considerable variation in infection and vaccination history by race/ethnicity and socioeconomic status.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available