Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 18, Issue 5, Pages 504-508Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2015.1130705
Keywords
Lamiaceae; Salvia grandifolia; diterpenoid; grandifolia G; hepatoprotective activity
Funding
- National Natural Science Foundation of China [21302227]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
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One new diterpenoid, grandifolia G (1), together with a known diterpenoid (6,7,8,8a-tetrahydro-6,6-dimethyl-2-oxonaphtho[1,8-bc]furan-3-yl)-4-methylfuran-3-carboxylic acid (2), was isolated from 70% EtOH extract of root of Salvia grandifolia. Their structures were determined by UV, IR, HRESIMS, NMR spectra. Compounds 1 and 2 (10M) exhibited hepatoprotective activities (61 and 55%) against DL-galactosamine-induced cell damage in HL-7702 cells.
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