Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 18, Issue 11, Pages 1057-1062Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2016.1184653
Keywords
Mycophenolic acid; MPA; adenosine; synthesis; antiproliferative activity
Funding
- Polish National Science Center (NCN) [2013/11/B/NZ7/04838]
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The new conjugates of mycophenolic acid (MPA) were obtained in the reaction of N-6-(-aminoalkyl)adenosines with MPA in the presence of EDCI as a coupling reagent. New compounds 4a-h were evaluated on leukemia cell line (Jurkat) and PBMC from healthy donors. Length of the linker influenced observed activity. The compound 4b possessing 1,3-diamine spacer exhibited the most promising results and can be considered to further investigations.
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