4.8 Article

The case for increasing diversity in tissue-based functional genomics datasets to understand human disease susceptibility

Journal

NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -

Publisher

NATURE PORTFOLIO
DOI: 10.1038/s41467-022-30650-8

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Funding

  1. Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health

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The lack of diversity in ancestry and tissue types in tissue-based functional genomics resources limits comprehensive investigation of gene regulation. Global efforts to increase tissue diversity will promote more equitable medical care.
Tissue-based functional genomics resources including molecular quantitative trait loci datasets lack diversity in ancestry and tissue types and thus are inadequate for comprehensively investigating gene regulation. Global efforts to increase the tissue diversity will help achieve more equitable medical care.

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