Related references
Note: Only part of the references are listed.SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions
Qiwei Jiang et al.
MOLECULAR CANCER (2021)
Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner
Jianping Guo et al.
ADVANCED SCIENCE (2021)
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions
Jianping Guo et al.
NATURE CELL BIOLOGY (2019)
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance
Jinfang Zhang et al.
NATURE (2018)
The functions and regulation of the PTEN tumour suppressor: new modes and prospects
Yu-Ru Lee et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
AKT Inhibition in Solid Tumors With AKT1 Mutations
David M. Hyman et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
Ahmet Zehir et al.
NATURE MEDICINE (2017)
AKT/PKB Signaling: Navigating the Network
Brendan D. Manning et al.
CELL (2017)
pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner
Jianping Guo et al.
SCIENCE (2016)
Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma
Marios Giannakis et al.
CELL REPORTS (2016)
Akt/PKB: one kinase, many modifications
Guillermo Risso et al.
BIOCHEMICAL JOURNAL (2015)
The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis
Lisa M. Ooms et al.
CANCER CELL (2015)
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
Pengda Liu et al.
CANCER DISCOVERY (2015)
PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction
Paolo Armando Gagliardi et al.
JOURNAL OF CELL BIOLOGY (2014)
Posttranslational regulation of Akt in human cancer
Chia-Hsin Chan et al.
CELL AND BIOSCIENCE (2014)
Sinl phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
Pengda Liu et al.
NATURE CELL BIOLOGY (2013)
PDK1 Signaling Toward PLK1-MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy
Jing Tan et al.
CANCER DISCOVERY (2013)
A Comprehensive Survey of Ras Mutations in Cancer
Ian A. Prior et al.
CANCER RESEARCH (2012)
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Jordi Barretina et al.
NATURE (2012)
Comprehensive molecular portraits of human breast tumours
Daniel C. Koboldt et al.
NATURE (2012)
The 16p13.3 (PDPK1) Genomic Gain in Prostate Cancer: A Potential Role in Disease Progression
Khalil A. Choucair et al.
TRANSLATIONAL ONCOLOGY (2012)
Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
Yonghao Yu et al.
SCIENCE (2011)
The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
Peggy P. Hsu et al.
SCIENCE (2011)
Phosphotyrosine Signaling: Evolving a New Cellular Communication System
Wendell A. Lim et al.
CELL (2010)
The nuts and bolts of AGC protein kinases
Laura R. Pearce et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Regulation of 3-Phosphoinositide-Dependent Protein Kinase 1 Activity by Homodimerization in Live Cells
Thomas A. Masters et al.
SCIENCE SIGNALING (2010)
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
Sophie Pinner et al.
NATURE CELL BIOLOGY (2008)
In vivo role of the phosphate groove of PDK1 defined by knockin mutation
BJ Collins et al.
JOURNAL OF CELL SCIENCE (2005)
PDK1, the master regulator of AGC kinase signal transduction
A Mora et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2004)
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
OJ Shah et al.
CURRENT BIOLOGY (2004)
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
LS Harrington et al.
JOURNAL OF CELL BIOLOGY (2004)
PI3K/Akt and apoptosis: size matters
TF Franke et al.
ONCOGENE (2003)
Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3
S Sato et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation
M Frödin et al.
EMBO JOURNAL (2002)
Essential role of PDK1 in regulating cell size and development in mice
MA Lawlor et al.
EMBO JOURNAL (2002)