Journal
NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-29864-7
Keywords
-
Categories
Funding
- National Institutes of Health [DC003180, DC005808]
- DARPA Cooperative Agreement [N66001-17-2-4008]
- Kavli Neuroscience Discovery Insitute at JHU
- NERC [NE/G001952/1]
- NSF [BCS 1304045, BCS 1540421]
- Trinity College of Arts and Sciences
Ask authors/readers for more resources
This study developed an optical imaging method for mapping cortical functions through the intact skull in marmoset monkeys. Detailed functions and topographies were revealed in visual, auditory, and somatosensory cortices at mesoscopic scales.
The primate cerebral cortex is organized into specialized areas representing different modalities and functions along a continuous surface. The functional maps across the cortex, however, are often investigated a single modality at a time (e.g., audition or vision). To advance our understanding of the complex landscape of primate cortical functions, here we develop a polarization-gated wide-field optical imaging method for measuring cortical functions through the un-thinned intact skull in awake marmoset monkeys (Callithrix jacchus), a primate species featuring a smooth cortex. Using this method, adjacent auditory, visual, and somatosensory cortices are noninvasively parcellated in individual subjects with detailed tonotopy, retinotopy, and somatotopy. An additional pure-tone-responsive tonotopic gradient is discovered in auditory cortex and a face-patch sensitive to motion in the lower-center visual field is localized near an auditory region representing frequencies of conspecific vocalizations. This through-skull landscape-mapping approach provides new opportunities for understanding how the primate cortex is organized and coordinated to enable real-world behaviors. The authors developed an optical imaging approach for mapping cortical functions through the intact skull in marmoset monkeys. Detailed functions and topographies were revealed in visual, auditory, and somatosensory cortices at mesoscopic scales.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available