Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy

Protecting the whole small intestine from radiation-induced intestinal injury during the radiotherapy of abdominal or pelvic solid tumors remains an unmet clinical need. Amifostine is a promising selective radioprotector for normal tissues. However, its oral application in intestinal radioprotection remains challenging. Herein, we use microalga Spirulina platensis as a microcarrier of Amifostine to construct an oral delivery system. The system shows comprehensive drug accumulation and effective radioprotection in the whole small intestine that is significantly superior to free drug and its enteric capsule, preventing the radiation-induced intestine injury and prolonging the survival without influencing the tumor regression. It also shows benefits on the gut microbiota homeostasis and long-term safety. Based on a readily available natural microcarrier, this work presents a convenient oral delivery system to achieve effective radioprotection for the whole small intestine, providing a competitive strategy with great clinical translation potential. Protecting the whole small intestine from radiation-induced intestinal injury during the radiotherapy of abdominal or pelvic solid tumors remains an unmet clinical need. Here the authors use a natural microalga to readily construct an oral delivery system to achieve effective radioprotection for the small intestine.

Automated summary

In this study, researchers have successfully developed an oral delivery system using Spirulina platensis as a microcarrier to protect the whole small intestine from radiation-induced injury during radiotherapy. The system accumulates the drug effectively and provides superior radioprotection compared to free drug and enteric capsules, preventing radiation-induced intestinal injury without affecting tumor regression. It also has benefits on gut microbiota homeostasis and long-term safety.