Journal
NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-28735-5
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Funding
- Brain Imaging and Genetics in Behavioral Research Consortium [40830]
- ERC [647648 EdGe]
- NSF Early Career Development Program grant [1942917]
- National Institute on Alcohol Abuse and Alcoholism [K23 AA023894]
- VISN 4 Mental Illness Research, Education and Clinical Center at the Crescenz VA Medical Center
- Division Of Behavioral and Cognitive Sci
- Direct For Social, Behav & Economic Scie [1942917] Funding Source: National Science Foundation
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Research shows negative associations between alcohol intake and brain macrostructure and microstructure, even in individuals with light-to-moderate alcohol consumption.
Heavy alcohol consumption has been associated with brain atrophy, neuronal loss, and poorer white matter fiber integrity. However, there is conflicting evidence on whether light-to-moderate alcohol consumption shows similar negative associations with brain structure. To address this, we examine the associations between alcohol intake and brain structure using multimodal imaging data from 36,678 generally healthy middle-aged and older adults from the UK Biobank, controlling for numerous potential confounds. Consistent with prior literature, we find negative associations between alcohol intake and brain macrostructure and microstructure. Specifically, alcohol intake is negatively associated with global brain volume measures, regional gray matter volumes, and white matter microstructure. Here, we show that the negative associations between alcohol intake and brain macrostructure and microstructure are already apparent in individuals consuming an average of only one to two daily alcohol units, and become stronger as alcohol intake increases. Heavy alcohol consumption has been associated with brain structural changes. Here, using data from the UK biobank, the authors report associations between alcohol intake and brain macrostructure and microstructure.
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