Journal
CURRENT ONCOLOGY REPORTS
Volume 24, Issue 5, Pages 659-670Publisher
SPRINGER
DOI: 10.1007/s11912-022-01223-1
Keywords
Fatty acid; Cancer immunotherapy; Tumor microenvironment; Immune cells
Categories
Funding
- National Natural Science Foundation of China [82073382]
- Fundamental Research Funds for the Central Universities [0214-14380506]
Ask authors/readers for more resources
This review provides an update on the latest findings concerning the impacts of FA metabolism reprogramming on the phenotypes and functions of immune cells in tumor-related immune responses. The combinatorial interventions of FA metabolism are also summarized, which can improve the effects of current immunotherapies.
Purpose of Review In this review, we update the latest findings on the impacts of FA metabolism reprogramming on the phenotypes and functions of immune cells in tumor-related immune responses. We also summarize the combinatorial interventions of FA metabolism, which improve the effects of current immunotherapies. Recent Findings Multiple studies have shown that either the abnormality in signaling pathways or nutrition competition in the TME can lead to phenotypic reprogramming of FA metabolism and functional changes in tumor-infiltrating immune cells, thereby influencing the therapeutic effects of cancer immunotherapies. Accordingly, regulating FA metabolism in immune cells has emerged and become promising approaches to synergize with immunotherapies. Summary One of the mechanisms behind suboptimal therapeutic effects of immunotherapies is metabolic reprogramming of the TME that impairs immunosuppressive activity. FA metabolism is a crucial process involved in the survival and function of primary immune cells. It is of great significance to explore the feasibility of overcoming FA metabolic barriers to improve cancer immunotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available