4.5 Review

DNMT1: catalytic and non-catalytic roles in different biological processes

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis

Jili Cui et al.

Summary: This study revealed that DNMT1 gene expression is upregulated in HNSCC and associated with poor prognosis, potentially involved in cell cycle, proliferation, and metabolic pathways. Significant differences in B cell infiltration were found based on TP53 mutation.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics

Yoon Jeong Park et al.

Summary: The study highlights the role of adipocyte-specific DNA methylation in regulating white adipose tissue plasticity and metabolic functions. Lack of DNA methylation disrupts adipocyte metabolism, leading to adipocyte hypertrophy and mitochondrial dysfunction, which increases the risk of obesity and metabolic complications.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Genetics & Heredity

Dysregulation of schizophrenia-associated genes and genome-wide hypomethylation in neurons overexpressing DNMT1

Sonal Saxena et al.

Summary: About 50% of dysregulated genes in schizophrenia patients also showed altered transcript levels in neurons with increased DNMT1, independently of DNA methylation. These neurons unexpectedly exhibited genome-wide hypomethylation, along with increased transcript levels of Tet1 and Apobec 1-3 genes, as well as increased activity and copy number of LINE-1 elements. The similarities observed between these neurons and schizophrenia brain samples suggest that DNMT1 overexpression could be a risk factor for schizophrenia.

EPIGENOMICS (2021)

Article Multidisciplinary Sciences

Mutation-induced DNMT1 cleavage drives neurodegenerative disease

Wencai Wang et al.

Summary: Specific mutations in the DNMT1 gene can cause neurodegenerative diseases, affecting both mice and humans. Mutant DNMT1 proteins are unstable due to cleavage within the RFTS domain, leading to functional defects. The study sheds light on the mechanisms underlying DNMT1 mutations and neurodegeneration.

SCIENCE ADVANCES (2021)

Article Biochemistry & Molecular Biology

DNMT1 mutations leading to neurodegeneration paradoxically reflect on mitochondrial metabolism

Alessandra Maresca et al.

HUMAN MOLECULAR GENETICS (2020)

Article Biochemistry & Molecular Biology

Virus-mediated Dnmt1 and Dnmt3a deletion disrupts excitatory synaptogenesis and synaptic function in primary cultured hippocampal neurons

Wei Sun et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biotechnology & Applied Microbiology

DNMT1 Enhances the Radiosensitivity of HPV-Positive Head and Neck Squamous Cell Carcinomas via Downregulating SMG1

Chunlin Zhang et al.

ONCOTARGETS AND THERAPY (2020)

Review Biochemistry & Molecular Biology

The DNA methylation landscape in cancer

Ksenia Skvortsova et al.

DNA METHYLATION (2019)

Review Genetics & Heredity

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

Frank Lyko

NATURE REVIEWS GENETICS (2018)

Article Biochemistry & Molecular Biology

Global delay in nascent strand DNA methylation

Jocelyn Charlton et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Global delay in nascent strand DNA methylation

Jocelyn Charlton et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Cell & Tissue Engineering

DNA Methyltransferases Modulate Hepatogenic Lineage Plasticity of Mesenchymal Stromal Cells

Chien-Wei Lee et al.

STEM CELL REPORTS (2017)

Article Multidisciplinary Sciences

Dnmt1 regulates the myogenic lineage specification of muscle stem cells

Renjing Liu et al.

SCIENTIFIC REPORTS (2016)

Article Developmental Biology

Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium

Ellen N. Elliott et al.

DEVELOPMENT (2015)

Article Genetics & Heredity

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells

Jing Liao et al.

NATURE GENETICS (2015)

Article Multidisciplinary Sciences

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

Rajneesh Pathania et al.

NATURE COMMUNICATIONS (2015)

Review Neurosciences

Epigenetic regulation of memory formation and maintenance

Iva B. Zovkic et al.

LEARNING & MEMORY (2013)

Article Biochemistry & Molecular Biology

Dissection of cell cycle-dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling

Katrin Schneider et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Biochemistry & Molecular Biology

Specificity of Dnmt1 for Methylation of Hemimethylated CpG Sites Resides in Its Catalytic Domain

Pavel Bashtrykov et al.

CHEMISTRY & BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Increased Expression of DNA methyltransferase 1 and 3a in Human Temporal Lobe Epilepsy

Qiong Zhu et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2012)

Article Oncology

On the presence and role of human gene-body DNA methylation

Daudi Jjingo et al.

ONCOTARGET (2012)

Article Genetics & Heredity

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases

Julia Arand et al.

PLOS GENETICS (2012)

Article Genetics & Heredity

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss

Christopher J. Klein et al.

NATURE GENETICS (2011)

Article Biochemistry & Molecular Biology

Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context

Jesus Espada et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Multidisciplinary Sciences

DNMT1 maintains progenitor function in self-renewing somatic tissue

George L. Sen et al.

NATURE (2010)

Article Neurosciences

Cortical DNA methylation maintains remote memory

Courtney A. Miller et al.

NATURE NEUROSCIENCE (2010)

Article Cell & Tissue Engineering

DNA Methyltransferase 1 Is Essential for and Uniquely Regulates Hematopoietic Stem and Progenitor Cells

Jennifer J. Trowbridge et al.

CELL STEM CELL (2009)

Article Biochemistry & Molecular Biology

Dimerization of DNA Methyltransferase 1 Is Mediated by Its Regulatory Domain

Karin Fellinger et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2009)

Article Multidisciplinary Sciences

Identification of a region of the DNMT1 methyltransferase that regulates the maintenance of genomic imprints

Ewa Borowczyk et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Developmental Biology

Preimplantation expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprints

M. Cecilia Cirio et al.

BMC DEVELOPMENTAL BIOLOGY (2008)

Review Genetics & Heredity

DNA polymerases and human disease

Lawrence A. Loeb et al.

NATURE REVIEWS GENETICS (2008)

Article Biochemistry & Molecular Biology

Biological functions of DNA methyltransferase 1 require its methyltransferase activity

Marc Damelin et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Neurosciences

Covalent modification of DNA regulates memory formation

Courtney A. Miller et al.

NEURON (2007)

Article Biochemistry & Molecular Biology

DNA methyltransferase 1 knockdown activates a replication stress checkpoint

Alexander Unterberger et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Geriatrics & Gerontology

Aging in heterozygous Dnmt1-deficient mice: Effects on survival, the DNA methylation genes, and the development of amyloidosis

D Ray et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2006)

Article Multidisciplinary Sciences

Recruitment of DNA methyltransferase I to DNA repair sites

O Mortusewicz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

In psychosis, cortical interneurons overexpress DNA-methyltransferase 1

M Veldic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Dnmt1 expression in pre- and postimplantation embryogenesis and the maintenance of IAP silencing

F Gaudet et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Replication-independent chromatin loading of Dnmt1 during G2 and M phases

HP Easwaran et al.

EMBO REPORTS (2004)

Article Biochemistry & Molecular Biology

Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I

JI Young et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

Induction of tumors in mice by genomic hypomethylation

F Gaudet et al.

SCIENCE (2003)

Article Biochemistry & Molecular Biology

Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality

D Biniszkiewicz et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Geriatrics & Gerontology

Unexpected effects of a heterozygous Dnmt1 null mutation on age-dependent DNA hypomethylation and autoimmunity

R Yung et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2001)

Article Multidisciplinary Sciences

CpG methylation is maintained in human cancer cells lacking DNMT1

I Rhee et al.

NATURE (2000)

Article Genetics & Heredity

Large-scale human promoter mapping using CpG islands

IP Ioshikhes et al.

NATURE GENETICS (2000)