Journal
EPIGENOMICS
Volume 14, Issue 10, Pages 629-643Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2022-0035
Keywords
cancer; cell proliferation; cellular plasticity; DNA methylation; DNA repair; DNMT1; non-catalytic activity; pluripotency
Categories
Funding
- Department of Biotechnology, Department of Science and Technology and Scientific Engineering Research Board
- Indian Council of Medical Research
- BITS Pilani
Ask authors/readers for more resources
DNMT1 is a key enzyme responsible for methylating the daughter strand in newly replicated DNA. Apart from its role in gene repression through methylation, recent data suggest that DNMT1 can also modulate gene expression independent of its catalytic activity and participate in various processes such as the cell cycle, DNA damage repair, and stem cell function.
DNMT1 is the main enzyme that uses the information on DNA methylation patterns in the parent strand and methylates the daughter strand in freshly replicated hemimethylated DNA. It is widely known that DNMT1 is a component of the epigenetic machinery mediating gene repression via increased promoter methylation. However, recent data suggest that DNMT1 can also modulate gene expression independent of its catalytic activity and participates in multiple processes including the cell cycle, DNA damage repair and stem cell function. This review summarizes the noncanonical functions of DNMT1, some of which are clearly independent of maintenance methylation. Finally, phenotypic data on altered DNMT1 levels suggesting that maintenance of optimal levels of DNMT1 is vital for normal development and health is presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available