Related references
Note: Only part of the references are listed.The Influence of Substitution on Thiol-Induced Oxanorbornadiene Fragmentation
Lucrezia De Pascalis et al.
ORGANIC LETTERS (2021)
Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Xiaobo Wan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles
Claudio Zambaldo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors
Kirsten McAulay et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins
Keisuke Tokunaga et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35
Thomas C. Atack et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
Covalent inhibitors: a rational approach to drug discovery
Fandi Sutanto et al.
RSC MEDICINAL CHEMISTRY (2020)
Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase
Yunhang Guo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology
Matthias Gehringer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
An Improved Process for the Preparation of a Covalent Kinase Inhibitor through a C-N Bond-Forming SNAr Reaction
Andrew T. Parsons et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2018)
The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC
Lixue Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2018)
Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery
Kenneth K. Hallenbeck et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2017)
Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR
Simon Planken et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Total Synthesis of (-)-Tetrodotoxin and 11-norTTX-6(R)-ol
Tomoaki Maehara et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family
Jeff B. Smaill et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies
Renato A. Bauer
DRUG DISCOVERY TODAY (2015)
The basics of thiols and cysteines in redox biology and chemistry
Leslie B. Poole
FREE RADICAL BIOLOGY AND MEDICINE (2015)
Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex
Nagendra Prasad Muddala et al.
MOLECULES (2015)
Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors
Mark E. Flanagan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer
Darren A. E. Cross et al.
CANCER DISCOVERY (2014)
Development of Enantioselective Synthetic Routes to the Hasubanan and Acutumine Alkaloids
Nicholas A. Calandra et al.
JOURNAL OF ORGANIC CHEMISTRY (2013)
Nano-fibrils formation of pBTTT via adding alkylthiol into solutions: Control of morphology and crystalline structure
Haiyang Wang et al.
POLYMER (2013)
Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles
Iana M. Serafimova et al.
NATURE CHEMICAL BIOLOGY (2012)
Substituent Effects on the Reversibility of Furan-Maleimide Cycloadditions
Robert C. Boutelle et al.
JOURNAL OF ORGANIC CHEMISTRY (2011)
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
D. Li et al.
ONCOGENE (2008)
Asymmetric synthesis of 4-amino-γ-butyrolactones via lithium amide conjugate addition
Elin Abraham et al.
TETRAHEDRON (2007)
Development of a multibed sorption trap, comprehensive two-dimensional gas chromatography, and time-of-flight mass spectrometry system for the analysis of volatile organic compounds in human breath
Juan M. Sanchez et al.
ANALYTICAL CHEMISTRY (2006)
Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase
SK Rabindran et al.
CANCER RESEARCH (2004)
Share Paper
