Journal
EXPERIMENTAL AND THERAPEUTIC MEDICINE
Volume 24, Issue 1, Pages -Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2022.11373
Keywords
cancer; cachexia; microRNAs; muscular atrophy
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This review discusses the role of miRNAs in the progression of cancer cachexia, as well as their diagnostic and potential therapeutic value.
Cachexia denotes a complex metabolic syndrome featuring severe loss of weight, fatigue and anorexia. In total, 50-80% of patients suffering from advanced cancer are diagnosed with cancer cachexia, which contributes to 40% of cancer-associated mortalities. MicroRNAs (miRNAs) are non-coding RNAs capable of regulating gene expression. Dysregulated miRNA expression has been observed in muscle tissue, adipose tissue and blood samples from patients with cancer cachexia compared with that of samples from patients with cancer without cachexia or healthy controls. In addition, miRNAs promote and maintain the malignant state of systemic inflammation, while inflammation contributes to cancer cachexia. The present review discusses the role of miRNAs in the progression of cancer cachexia, and assess their diagnostic value and potential therapeutic value.
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