4.7 Article

Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Targeting the Integrated Stress Response in Cancer Therapy

Xiaobing Tian et al.

Summary: The ISR is an evolutionarily conserved intra-cellular signaling network activated in response to intrinsic and extrinsic stresses, regulating protein synthesis and mRNA translation through eIF2 alpha phosphorylation. While promoting cell survival and homeostasis, severe or prolonged stress can shift ISR signaling to regulate cellular apoptosis.

FRONTIERS IN PHARMACOLOGY (2021)

Review Cell Biology

Critical View of Novel Treatment Strategies for Glioblastoma: Failure and Success of Resistance Mechanisms by Glioblastoma Cells

Timo Burster et al.

Summary: The invasive nature of glioblastoma poses challenges to standard care, as conventional therapies have failed to completely eradicate glioblastoma cells. New approaches including small molecule inhibitors, immunotherapy, and virotherapy, focus on boosting the host immune system to interfere with immune evasion of glioblastoma cells, showing promise for therapeutic applications.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Clinical Neurology

MEK Inhibition Suppresses Growth of Atypical Teratoid/Rhabdoid Tumors

Shubin Shahab et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2020)

Review Oncology

Targeting mTOR for cancer therapy

Hui Hua et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Review Oncology

NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega et al.

CANCER CELL (2018)

Review Cell Biology

Glutathione metabolism in cancer progression and treatment resistance

Ankita Bansal et al.

JOURNAL OF CELL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

The Unfolded Protein Response and Cell Fate Control

Claudio Hetz et al.

MOLECULAR CELL (2018)

Review Oncology

mTOR signalling and cellular metabolism are mutual determinants in cancer

Dirk Mossmann et al.

NATURE REVIEWS CANCER (2018)

Review Biochemistry & Molecular Biology

BCL-2 family proteins: changing partners in the dance towards death

Justin Kale et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Biochemistry & Molecular Biology

WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit

Jing Wang et al.

NUCLEIC ACIDS RESEARCH (2017)

Review Biochemistry & Molecular Biology

BCL-2 family: integrating stress responses at the ER to control cell demise

Philippe Pihan et al.

CELL DEATH AND DIFFERENTIATION (2017)

Article Biochemistry & Molecular Biology

The integrated stress response and proteotoxicity in cancer therapy

David J. McConkey

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Review Biochemistry & Molecular Biology

The integrated stress response

Karolina Pakos-Zebrucka et al.

EMBO REPORTS (2016)

Article Multidisciplinary Sciences

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Andras Kotschy et al.

NATURE (2016)

Review Biochemistry & Molecular Biology

The Dual Roles of NRF2 in Cancer

Silvia Menegon et al.

TRENDS IN MOLECULAR MEDICINE (2016)

Article Clinical Neurology

The Chromatin-Modifying Protein HMGA2 Promotes Atypical Teratoid/Rhabdoid Cell Tumorigenicity

Harpreet Kaur et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2015)

Article Multidisciplinary Sciences

The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest

Manuel D. Haschka et al.

NATURE COMMUNICATIONS (2015)

Article Oncology

PID1 (NYGGF4), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas

Anat Erdreich-Epstein et al.

CLINICAL CANCER RESEARCH (2014)

Review Biotechnology & Applied Microbiology

PI3K and cancer: lessons, challenges and opportunities

David A. Fruman et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Biochemistry & Molecular Biology

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao et al.

SCIENCE SIGNALING (2013)

Article Radiology, Nuclear Medicine & Medical Imaging

mTOR Signaling, Function, Novel Inhibitors, and Therapeutic Targets

Ryosuke Watanabe et al.

JOURNAL OF NUCLEAR MEDICINE (2011)

Article Oncology

A phase I study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in solid tumor malignancies

Paul K. Paik et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2010)

Article Biochemistry & Molecular Biology

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Juan M. Garcia-Martinez et al.

BIOCHEMICAL JOURNAL (2009)

Article Multidisciplinary Sciences

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

Mai Nguyen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Novel role for insulin as an autocrine growth factor for malignant brain tumour cells

Alexandre Arcaro et al.

BIOCHEMICAL JOURNAL (2007)

Review Biochemistry & Molecular Biology

Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway

SB Cullinan et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)