Journal
CELL DEATH & DISEASE
Volume 13, Issue 3, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41419-022-04713-z
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Funding
- Basic and Applied Basic Research fund of Guangdong Province [2021A1515012553, 2019A1515110123]
- Ministry of Science and Technology of the People's Republic of China [2017ZX10201101, 2020YFC2002705]
- National Key Research and Development Program of China [2017YFA0505103]
- National Natural Science Foundation of China [21877068, 20211300114]
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Nicotinamide N-methyltransferase (NNMT) plays critical roles in cancer progression by affecting cellular methylation reactions and signaling pathways, and it has been identified as a potential biomarker and therapeutic target for tumor diagnosis and treatment.
Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-l-methionine (SAM) is the methyl donor. High expression of NNMT can alter cellular NAM and SAM levels, which in turn, affects nicotinamide adenine dinucleotide (NAD(+))-dependent redox reactions and signaling pathways, and remodels cellular epigenetic states. Studies have revealed that NNMT plays critical roles in the occurrence and development of various cancers, and analysis of NNMT expression levels in different cancers from The Cancer Genome Atlas (TCGA) dataset indicated that NNMT might be a potential biomarker and therapeutic target for tumor diagnosis and treatment. This review provides a comprehensive understanding of recent advances on NNMT functions in different tumors and deciphers the complex roles of NNMT in cancer progression.
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