4.7 Review

Mechanism of cancer stemness maintenance in human liver cancer

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

CRISPR/Cas9-mediated knockout of PIM3 suppresses tumorigenesis and cancer cell stemness in human hepatoblastoma cells

Raoud Marayati et al.

Summary: This study successfully knocked out the PIM3 gene using CRISPR/Cas9 technology, and found that PIM3 knockout significantly reduced proliferation, viability, and motility of hepatoblastoma cells, inhibited cell-cycle progression, and decreased tumor growth in a xenograft murine model.

CANCER GENE THERAPY (2022)

Article Multidisciplinary Sciences

Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity

Brijesh Kumar et al.

Summary: This study found that evaluating tumor cells under physiological oxygen conditions could more accurately simulate their physiological and pathological state in the in vivo microenvironment. It showed significant differences in key signaling networks, nuclear reactive oxygen species, alternative splicing, and sensitivity to targeted therapies compared to evaluating tumor cells at ambient air conditions.

SCIENCE ADVANCES (2022)

Article Gastroenterology & Hepatology

CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5-lipoxygenase

Yuli Lin et al.

Summary: This study demonstrates that cancer-associated fibroblasts (CAFs) promote cancer stemness by regulating myeloid-derived suppressor cells (MDSCs) in intrahepatic cholangiocarcinoma (ICC). The 5-LO/LTB4-BLT2 axis may serve as promising therapeutic targets for overcoming ICC chemoresistance by targeting cancer stemness.

HEPATOLOGY (2022)

Article Gastroenterology & Hepatology

DCLK1, a Putative Stem Cell Marker in Human Cholangiocarcinoma

Nevi Lorenzo et al.

Summary: The study evaluated the expression and function of DCLK1 in intrahepatic and perihilar cholangiocarcinoma cells. DCLK1 was identified as a specific CSC marker and its inhibitor showed anti-neoplastic effects. In addition, DCLK1 was found to be highly expressed in tumor tissues and may serve as a serum biomarker for early diagnosis of cholangiocarcinoma.

HEPATOLOGY (2021)

Article Biochemistry & Molecular Biology

Cell softness regulates tumorigenicity and stemness of cancer cells

Jiadi Lv et al.

Summary: Microfluidic devices can sort cancer stem cells into mechanically stiff and soft subpopulations, with soft tumor cells showing higher tumorigenicity. The upregulation of Wnt signaling protein BCL9L in soft tumor cells is associated with their stemness and tumorigenicity. These findings suggest that intrinsic softness can serve as a unique marker for highly tumorigenic and metastatic tumor cells.

EMBO JOURNAL (2021)

Article Oncology

S100 calcium-binding protein A9 from tumor-associated macrophage enhances cancer stem cell-like properties of hepatocellular carcinoma

Ran Wei et al.

Summary: The study revealed that TAMs can enhance the stem cell-like properties of HCC cells by upregulating the secreted protein S100A9, which in turn activates the NF-kB signaling pathway. Additionally, S100A9 can promote the recruitment of macrophages to HCC cells, suggesting a positive feedback loop between TAMs and HCC cells.

INTERNATIONAL JOURNAL OF CANCER (2021)

Article Gastroenterology & Hepatology

Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma

Chiara Raggi et al.

Summary: The study reveals that cancer stem cells in cholangiocarcinoma have a more efficient respiratory phenotype, relying on mitochondrial oxidative metabolism and PGC-1a to maintain CSC features. Targeting mitochondrial complex I or PGC-1a in CCA-SPH impairs spherogenicity and expression of markers related to CSC phenotype, pluripotency, and epithelial-mesenchymal transition. Administration of metformin or SR-18292 in mice with CCA-SPH xenografts significantly reduces tumor growth and reverts the phenotype to that of cells grown in monolayer.

JOURNAL OF HEPATOLOGY (2021)

Article Chemistry, Multidisciplinary

Chemotherapy-Enriched THBS2-Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications

Kai-Yu Ng et al.

Summary: The study reveals the role of chemotherapy-enriched CD133+ liver cancer stem cells with THBS2 deficiency in promoting an aggressive hepatocellular carcinoma phenotype by remodeling the extracellular matrix. THBS2 deficiency is associated with low HCC survival and the findings have implications for cancer treatment.

ADVANCED SCIENCE (2021)

Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Medicine, Research & Experimental

CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells

Xiaoxue Jiang et al.

Summary: CircMEG3 is downregulated in human liver cancer and inhibits the growth and differentiation of liver cancer stem cells through various mechanisms, providing potential therapeutic targets for liver cancer treatment.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Review Cell Biology

Iron Metabolism in the Tumor Microenvironment-Implications for Anti-Cancer Immune Response

Alessandro Sacco et al.

Summary: New insights have been gained into the impact of iron metabolism within the tumor microenvironment on cancer development. Iron promotes the production of reactive oxygen species, which can trigger cell death or malignant transformation, affecting tumor immunosurveillance. The potential and controversies of using iron metabolism as a target for anticancer treatments are discussed, particularly in the context of hot and cold tumors.

CELLS (2021)

Article Biochemistry & Molecular Biology

Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production

Kunlun Yin et al.

Summary: Research has shown that the mitochondria protein PINK1 suppresses colon tumor growth by metabolic reprogramming and reducing acetyl-CoA production. PINK1 overexpression promotes mitophagy, decreases glycolysis, and increases mitochondrial respiration, while PINK1 deletion leads to decreased apoptosis, increased glycolysis, and reduced mitochondrial respiration.

CELL DEATH AND DIFFERENTIATION (2021)

Article Multidisciplinary Sciences

Comprehensive analysis of spatial architecture in primary liver cancer

Rui Wu et al.

Summary: The study constructed a high-resolution spatial transcriptome map of primary liver cancers and revealed the evolution of tumor microenvironment characteristics from nontumor to tumor regions. It proposed a signature for accurately locating tertiary lymphoid structures spatially and identified interactions related to TME remodeling and tumor metastasis.

SCIENCE ADVANCES (2021)

Article Cell Biology

A Ferroptosis and Pyroptosis Molecular Subtype-Related Signature Applicable for Prognosis and Immune Microenvironment Estimation in Hepatocellular Carcinoma

Junyu Huo et al.

Summary: The molecular subtype-related signature of ferroptosis and pyroptosis identified and validated in this study is applicable for prognosis prediction, immune microenvironment estimation, stem cell characteristics, and clinical feature assessment in HCC.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

Epigenetic Induction of Mitochondrial Fission Is Required for Maintenance of Liver Cancer-Initiating Cells

Miaoling Tang et al.

Summary: In liver cancer cells, the upregulation of MFF mediated by the TBX19/PRMT1 complex promotes mitochondrial fission and tumor-initiating capacity, indicating that PRMT1 may be a viable therapeutic target in liver cancer.

CANCER RESEARCH (2021)

Article Gastroenterology & Hepatology

DNMT1-mediated methylation of BEX1 regulates stemness and tumorigenicity in liver cancer

Qian Wang et al.

Summary: BEX1 plays a crucial role in regulating cancer stem cell properties in hepatoblastoma and a subtype of hepatocellular carcinoma with high CSC features by activating Wnt/beta-catenin signaling. Targeting BEX1-mediated signaling pathways may provide a potential therapeutic strategy to address the high recurrence rate and heterogeneity of liver cancer.

JOURNAL OF HEPATOLOGY (2021)

Article Gastroenterology & Hepatology

STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway

Laura Conde de la Rosa et al.

Summary: The study revealed an unrecognized role of STARD1 in the pathogenesis of HCC, promoting the synthesis of primary BAs through the mitochondrial pathway, which stimulate hepatocyte pluripotency, self-renewal, and inflammation in tumour-initiated stem-like cells (TICs).

JOURNAL OF HEPATOLOGY (2021)

Article Multidisciplinary Sciences

The inhibition of ABCB1/MDR1 or ABCG2/BCRP enables doxorubicin to eliminate liver cancer stem cells

Wang Yin et al.

Summary: Inhibiting MDR1 or ABCG2 was found to increase the sensitivity of liver cancer stem cells to doxorubicin, leading to elevated intracellular concentration of the drug and increased apoptosis. This approach effectively reversed chemoresistance in liver cancer stem cells, demonstrating a promising strategy for enhancing the therapeutic efficacy of doxorubicin.

SCIENTIFIC REPORTS (2021)

Review Pharmacology & Pharmacy

Role of Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy

Jianming Hu et al.

Summary: Accumulating evidence suggests that cancer stem cells (CSCs) are significantly involved in cancer initiation, therapy resistance, recurrence, and metastasis. Abnormal lipid metabolism is associated with cancer stemness, and utilizing lipid metabolism-related treatment strategies may hold promise for future cancer therapies.

FRONTIERS IN PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Targeted Inhibition of LPL/FABP4/CPT1 fatty acid metabolic axis can effectively prevent the progression of nonalcoholic steatohepatitis to liver cancer

Haoran Yang et al.

Summary: The upregulation of the LPL/FABP4/CPT1 molecular axis during NASH phase is specific and inhibiting it can delay tumor growth and significantly reduce the viability of liver cancer stem cells.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Oncology

Dual Targeting of Sorafenib-Resistant HCC-Derived Cancer Stem Cells

Ritu Shrestha et al.

Summary: The study aimed to target chemoresistant CSC population in HCC by evaluating the effectiveness of a combination treatment approach with Sorafenib, an EMT inhibitor, and an immune checkpoint inhibitor. The results showed that the combination of SB431542 and siRNA-mediated knockdown of PD-L1 or CD73 effectively enhanced the cytotoxicity of Sorafenib against the CSC population, reducing the size and proliferation of spheres and inducing apoptosis.

CURRENT ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

Xiaoge Hu et al.

CELL DEATH AND DIFFERENTIATION (2020)

Review Gastroenterology & Hepatology

Epitranscriptomics in liver disease: Basic concepts and therapeutic potential

Zhicong Zhao et al.

JOURNAL OF HEPATOLOGY (2020)

Article Chemistry, Analytical

Metabolic Activity Phenotyping of Single Cells with Multiplexed Vibrational Probes

Zhilun Zhao et al.

ANALYTICAL CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

CD44 regulates epigenetic plasticity by mediating iron endocytosis

Sebastian Mueller et al.

NATURE CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

A Lipidomic Signature Complements Stemness Features Acquisition in Liver Cancer Cells

Irma Magaly Rivas Serna et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

The interaction between ferroptosis and lipid metabolism in cancer

Dingshan Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Biochemistry & Molecular Biology

A Soft Matrix Enhances the Cancer Stem Cell Phenotype of HCC Cells

Boren Tian et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Genetics & Heredity

Cancer-associated fibroblasts promote the stemness of CD24+ liver cells via paracrine signaling

Yawen Li et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2019)

Article Multidisciplinary Sciences

Necroptosis microenvironment directs lineage commitment in liver cancer

Marco Seehawer et al.

NATURE (2018)

Article Gastroenterology & Hepatology

Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages

Chiara Raggi et al.

JOURNAL OF HEPATOLOGY (2017)

Article Biochemistry & Molecular Biology

Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells

Kai Liu et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133

Wonhee Hur et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Fatty acid-related modulations of membrane fluidity in cells: detection and implications

G. Maulucci et al.

FREE RADICAL RESEARCH (2016)

Article Multidisciplinary Sciences

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

Diwakar R. Pattabiraman et al.

SCIENCE (2016)

Review Medicine, Research & Experimental

The role for autophagy in cancer

Eileen White

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biochemistry & Molecular Biology

CD90+liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA

Alice Conigliaro et al.

MOLECULAR CANCER (2015)

Article Gastroenterology & Hepatology

Epigenetic Reprogramming Modulates Malignant Properties of Human Liver Cancer

Chiara Raggi et al.

HEPATOLOGY (2014)

Article Gastroenterology & Hepatology

Inflammatory Cytokines Promote the Retrodifferentiation of Tumor-Derived Hepatocyte-Like Cells to Progenitor Cells

Helene Dubois-Pot-Schneider et al.

HEPATOLOGY (2014)

Article Gastroenterology & Hepatology

Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression

Yoshifumi Morita et al.

JOURNAL OF HEPATOLOGY (2013)

Article Multidisciplinary Sciences

Metformin, a Diabetes Drug, Eliminates Tumor-Initiating Hepatocellular Carcinoma Cells

Tomoko Saito et al.

PLOS ONE (2013)

Review Oncology

The roles of TGFβ in the tumour microenvironment

Michael Pickup et al.

NATURE REVIEWS CANCER (2013)

Article Integrative & Complementary Medicine

Herbal Compound Songyou Yin Renders Hepatocellular Carcinoma Sensitive to Oxaliplatin through Inhibition of Stemness

Qing-An Jia et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012)

Article Gastroenterology & Hepatology

EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

Taro Yamashita et al.

GASTROENTEROLOGY (2009)

Review Gastroenterology & Hepatology

Mechanisms of hepatic fibrogenesis

Scott L. Friedman

GASTROENTEROLOGY (2008)

Article Multidisciplinary Sciences

Dissecting direct reprogramming through integrative genomic analysis

Tarjei S. Mikkelsen et al.

NATURE (2008)

Review Biochemistry & Molecular Biology

Mammalian DNA methyltransferases: A structural perspective

Xiaodong Cheng et al.

STRUCTURE (2008)

Article Biochemistry & Molecular Biology

CD133+ hepatic stellate cells are progenitor cells

Claus Kordes et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Multidisciplinary Sciences

The Hedgehog and Wnt signaling pathways in cancer

J Taipale et al.

NATURE (2001)