Journal
CELL DEATH & DISEASE
Volume 13, Issue 4, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41419-022-04791-z
Keywords
-
Categories
Funding
- Ministry of Science and Technology, Taiwan [MOST108-2314-B-341-001, MOST-109-2320-B-341-002-, MOST 110-2314-B-341-001MY2]
- Shin Kong Wu Ho-Su Memorial Hospital [2019SKHBDR001, 2020SKHBDR001, 2020SKHBDR002]
Ask authors/readers for more resources
This study suggests the potential use of hsa-miR-30a-3p as a therapeutic intervention in bladder cancer. By suppressing the expression of matrix metalloproteinase-2 and MMP-9 and improving the chemosensitivity of bladder cancer cells, hsa-miR-30a-3p may reduce invasive potential and enhance the effectiveness of chemotherapy.
Bladder cancer (BC) is the second most common urologic cancer in western countries. New strategies for managing high-grade muscle-invasive bladder cancer (MIBC) are urgently required because MIBC has a high risk of recurrence and poor survival. A growing body of evidence indicates that microRNA has potent antitumorigenic properties in various cancers, and thus, therapeutic strategies based on microRNA may show promising results in cancer therapy. Analysis of The Cancer Genome Atlas (TCGA) database indicated that hsa-miR-30a-3p is downregulated in human BC. Our in vitro investigation demonstrated that hsa-miR-30a-3p suppresses the expression of matrix metalloproteinase-2 (MMP-2) and MMP-9 and reduces the cell invasive potential of BC cells. Furthermore, hsa-miR-30a-3p directly targets ATG5, ATG12, and Beclin 1; this in turn improves the chemosensitivity of BC cells to cisplatin through the repression of protective autophagy. In a tumor-xenograft mice model, hsa-miR-30a-3p suppressed muscle invasion. Cotreatment with hsa-miR-30a-3p enhanced the antitumor effect of cisplatin in reducing tumor growth in BC. The current study provides a novel strategy of using hsa-miR-30a-3p as an adjuvant or replacement therapy in future BC treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available