Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 93, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2022.105063
Keywords
Corn peptides; NAFLD; Endoplasmic reticulum stress; AMPK alpha/Sirt1 pathway
Categories
Funding
- National Natural Science Foundation of China [82073531]
Ask authors/readers for more resources
The study shows that corn peptides have antioxidant and detoxifying effects in vivo and in vitro models, and improve lipid metabolism by activating the AMPK alpha/Sirt1 pathway. This suggests that corn peptides could be a promising functional food for preventing nonalcoholic fatty liver disease.
Corn peptides (CPs) are a novel food obtained from the enzymatic hydrolysis of corn gluten meal. Recent studies indicate the hepatoprotective ability of CPs. However, little is known about the effect of CPs on nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the effect of CPs in NAFLD and to decipher the underlying mechanisms. We show that CPs contain large number of antioxidant peptides. They significantly ameliorated oxidative and endoplasmic reticulum stress, and downregulated lipid metabolism-related proteins in in vivo and in vitro models. The AMPK alpha/Sirt1 pathway was activated by CPs, as was evident through the incubation of cells with the AMPK inhibitor, Compound C. These results demonstrate that CPs could be a promising functional food for preventing NAFLD progression, at least in part through activation of the AMPK alpha/Sirt1 pathway.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available