Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 92, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2022.105034
Keywords
Aronia melanocarpa; Cyanidin-3-galactoside; Pulmonary fibrosis; Fibroblast differentiation; Oxidative stress
Categories
Funding
- Educational Department of Liaoning Province [LJKZ0652]
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C3G extracted from Aronia melanocarpa inhibits fibroblast differentiation and reduces silica particle-induced pulmonary fibrosis through antioxidant effects. It also regulates the balance of oxidation and antioxidant in the lungs, downregulates fibroblast markers, and decreases the secretion of pro-fibrotic factors.
Aronia melanocarpa is rich in anthocyanins with many beneficial effects. Cyanidin-3-galactoside (C3G), the most abundant anthocyanin in Aronia melanocarpa was extracted and applied to silica particle-induced (SP-induced) pulmonary fibrosis mice and transforming growth factor-beta-induced differentiation of NIH3T3 fibroblasts cell line to investigate the anti-fibrotic properties and underlying cellular mechanisms. The administration of C3G inhibited fibroblast differentiation through antioxidant effects, thereby reducing SP-induced pulmonary fibrosis. In vivo experiments showed that C3G reduced the fibrous nodules and collagen deposition in the lungs, the level of fibroblast markers, and the secretion of pro-fibrotic factors. C3G can also maintain the balance of oxidation and antioxidant in the lungs of mice, inhibit the phosphorylation of mitogen-activated protein kinase p38 and protein kinase B, down-regulate the level of NADPH oxidase 4 and increase the level of nuclear factor (erythroidderived 2) like 2 express. The in vitro mechanism study of NIH3T3 cells verified the results of in vivo experiments. These findings emphasized the potential use of C3G as a functional food to alleviate SP-induced pulmonary fibrosis.
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