Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 91, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2022.105001
Keywords
Tea saponin; Camellia oleifera Abel. seed pomace; Anti-inflammatory; Antipruritic; UHPLC-Q-exactive orbitrap-MS; Atopic dermatitis
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This study evaluated the therapeutic effects of tea saponin from seed pomace of C. oleifera on atopic dermatitis. The results showed that tea saponin possesses antipruritic and anti-inflammatory properties, significantly reducing dermatitis and scratching in mice. It also normalized the skin barriers and inhibited the generation of inflammatory cytokines.
Tea saponin (TS) has antibacterial and anti-inflammatory properties. However, the antipruritic and anti-inflammatory effects on atopic dermatitis (AD) are unknown. This study, therefore, evaluated the therapeutic effects of TS from seed pomace of C. oleifera on AD in 2,4-Dinitrochlombenzene (DNCB)-caused BALB/c mice. The major compositions were separated and analyzed by ultrahigh-performance liquid chromatography Q-Exactive Orbitrap mass spectrometry. The antipruritic efficacy as well as the anti-inflammatory activity of TS were assessed using skin lesions, scratching tendency, and cytokine levels in DNCB-caused BALB/c mice. Twenty-six TS were preliminarily identified, and the dermatitis results revealed that TS could significantly reduce the degree of dermatitis and scratching in AD mice induced by DNCB. TS also normalized the skin barriers and inhibited the generation of inflammatory cytokines in the serum and skin tissue of mice. Overall, TS possesses antipruritic and anti-inflammatory properties, making it a potential natural resource for dermatitis treatment.
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