4.7 Article

α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase

Journal

JOURNAL OF FUNCTIONAL FOODS
Volume 92, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.jff.2022.105041

Keywords

Fatty acid synthase; alpha-Linolenic acid; Inhibitor; Breast cancer cells; Cell apoptosis

Funding

  1. Strategic Priority Research Program of the Chinese Academy of Sciences [XDA23080601]
  2. Fundamental Research Funds for the Central Universities [2012315]
  3. Youth Innovation Promotion Association, CAS

Ask authors/readers for more resources

This study found that alpha-linolenic acid (ALA) inhibits the fatty acid synthesis pathway in breast cancer cells, inducing cell apoptosis and inhibiting invasion, metastasis, and cell cycle progression.
Fatty acid synthase (FASN) is an enzyme that synthesizes endogenous fatty acids. FASN overexpressed in various cancers, which indicates the involvement of FASN in cancer progression. alpha-Linolenic acid (ALA) is an omega-3 fatty acid with many biological activities, including anti-cancer effects. The aim of the present study was to investigate the inhibitory effect of ALA on fatty acid synthesis pathway and breast cancer cells apoptosis. We found FASN expression decreased significantly in ALA treated breast cancer cells. Compared with palmitic acid (PA), ALA reduced cell viability in a dose-dependent manner. ALA showed a higher affinity with the TE domain than PA. ALA induced breast cancer cells apoptosis, which effects were similar with the knockdown of FASN. In addition, ALA inhibited the invasion and metastasis, and arrested cell cycle in breast cancer cells. We propose a hypothesis that ALA could contribute to the treatment of human breast cancer by inhibiting FASN.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available