Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 92, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2022.105041
Keywords
Fatty acid synthase; alpha-Linolenic acid; Inhibitor; Breast cancer cells; Cell apoptosis
Categories
Funding
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA23080601]
- Fundamental Research Funds for the Central Universities [2012315]
- Youth Innovation Promotion Association, CAS
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This study found that alpha-linolenic acid (ALA) inhibits the fatty acid synthesis pathway in breast cancer cells, inducing cell apoptosis and inhibiting invasion, metastasis, and cell cycle progression.
Fatty acid synthase (FASN) is an enzyme that synthesizes endogenous fatty acids. FASN overexpressed in various cancers, which indicates the involvement of FASN in cancer progression. alpha-Linolenic acid (ALA) is an omega-3 fatty acid with many biological activities, including anti-cancer effects. The aim of the present study was to investigate the inhibitory effect of ALA on fatty acid synthesis pathway and breast cancer cells apoptosis. We found FASN expression decreased significantly in ALA treated breast cancer cells. Compared with palmitic acid (PA), ALA reduced cell viability in a dose-dependent manner. ALA showed a higher affinity with the TE domain than PA. ALA induced breast cancer cells apoptosis, which effects were similar with the knockdown of FASN. In addition, ALA inhibited the invasion and metastasis, and arrested cell cycle in breast cancer cells. We propose a hypothesis that ALA could contribute to the treatment of human breast cancer by inhibiting FASN.
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