4.7 Article

Ferulic acid targets ACSL1 to ameliorate lipid metabolic disorders in db/db mice

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Trans-ferulic acid attenuates hyperglycemia-induced oxidative stress and modulates glucose metabolism by activating AMPK signaling pathway in vitro

Sangeetha S. B. Singh et al.

Summary: This study demonstrated that trans-ferulic acid (TFA) acts as a potent activator of AMPK under hyperglycemic conditions in liver cells and skeletal muscle cells. TFA exerts its therapeutic effects by reducing oxidative stress, increasing glutathione levels, upregulating glucose transporters, and inhibiting JNK1/2 activation.

JOURNAL OF FOOD BIOCHEMISTRY (2022)

Article Chemistry, Multidisciplinary

Ursolic acid reduces hepatocellular apoptosis and alleviates alcohol-induced liver injury via irreversible inhibition of CASP3 in vivo

Xiao-yao Ma et al.

Summary: This study utilized an alkynyl-modified UA probe to identify CASP3 as the primary target protein of UA associated with liver protection. Through molecular docking analysis, it was found that the epoxy group of UA metabolite reacted with Cys-163 of CASP3, implying the inhibition mechanism of CASP3 by UA. Additionally, the study demonstrated that UA could alleviate alcohol-induced liver injury by inhibiting CASP3 in a dose-dependent manner.

ACTA PHARMACOLOGICA SINICA (2021)

Article Pharmacology & Pharmacy

ACSL family: The regulatory mechanisms and therapeutic implications in cancer

Jing Quan et al.

Summary: The deregulation of fatty acid metabolism is associated with cancer development, with ACSL family members playing different roles in cancer progression, some promoting cancer and some having inhibitory effects, while also participating in cell death processes. ACSLs may serve as important therapeutic targets and biomarkers for cancer treatment.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Review Medicine, Research & Experimental

Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives

Dan Li et al.

Summary: Ferulic acid, a phenolic substance widely found in plants, has been shown to have various biological activities such as antioxidative, anti-inflammatory, anti-apoptotic, and vascular protective effects. Its mechanisms of action involve inhibition of certain signaling pathways and enzymes related to oxidative stress, inflammation, and fibrosis.

LIFE SCIENCES (2021)

Review Cardiac & Cardiovascular Systems

Coffee consumption and cardiovascular diseases and mortality in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of cohort studies

Hossein Shahinfar et al.

Summary: The study found an inverse association between consuming 4 cups of coffee per day and all-cause mortality, CVD mortality, CHD mortality, CHD, and total CVD events in patients with type 2 diabetes. However, no significant association was found for cancer mortality and stroke.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

Review Biochemistry & Molecular Biology

Clinical lipidomics: realizing the potential of lipid profiling

Thomas G. Meikle et al.

Summary: Dysregulation of lipid metabolism plays a major role in various diseases, and recent advances in lipidomic methodology allow comprehensive profiling of clinical samples, aiding researchers in associating lipid species with disease onset and progression to develop risk assessment models. The future development of purpose-built clinical platforms may assist healthcare providers with disease risk assessment, diagnosis, and monitoring.

JOURNAL OF LIPID RESEARCH (2021)

Article Biochemistry & Molecular Biology

An Essential Role of the N-Terminal Region of ACSL1 in Linking Free Fatty Acids to Mitochondrial β-Oxidation in C2C12 Myotubes

Jinyan Nan et al.

Summary: The study showed that ACSL1 localizes to the outer membrane of mitochondria in C2C12 myotubes through interaction with CPT1b, and overexpression of ACSL1 increased FAO rates and improved insulin resistance. Targeting ACSL1 to mitochondria is crucial for enhancing FAO in myotubes and reducing insulin resistance in obesity-related metabolic disorders.

MOLECULES AND CELLS (2021)

Review Food Science & Technology

Novel insights in health-promoting properties of sweet cherries

Maria Felicia Faienza et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

Review Medicine, General & Internal

The Lancet Commission on diabetes: using data to transform diabetes care and patient lives

Juliana C. N. Chan et al.

LANCET (2020)

Article Endocrinology & Metabolism

A Vegetable Dietary Pattern Is Associated with Lowered Risk of Gestational Diabetes Mellitus in Chinese Women

Qiong Chen et al.

DIABETES & METABOLISM JOURNAL (2020)

Article Biochemistry & Molecular Biology

Ferulic acid confers protection on islet β cells and placental tissues of rats with gestational diabetes mellitus

Jian Zhao et al.

CELLULAR AND MOLECULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

It takes a village: channeling fatty acid metabolism and triacylglycerol formation via protein interactomes

Rosalind A. Coleman

JOURNAL OF LIPID RESEARCH (2019)

Review Biochemistry & Molecular Biology

An Insight into the Therapeutic Potential of Major Coffee Components

Muhammad Torequl Islam et al.

CURRENT DRUG METABOLISM (2018)

Review Physiology

INTERORGAN METABOLIC CROSSTALK IN HUMAN INSULIN RESISTANCE

Sofiya Gancheva et al.

PHYSIOLOGICAL REVIEWS (2018)

Article Biochemistry & Molecular Biology

Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways

Pamela A. Young et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Letter Medicine, General & Internal

Prevalence of the Metabolic Syndrome in the United States, 2003-2012

Maria Aguilar et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

Review Biochemistry & Molecular Biology

Physiological Consequences of Compartmentalized Acyl-CoA Metabolism

Daniel E. Cooper et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Review Gastroenterology & Hepatology

Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: An update

Sheng Yan et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

Article Pharmacology & Pharmacy

Protective effect of ferulic acid and resveratrol against alloxan-induced diabetes in mice

Manikandan Ramar et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2012)

Article Gastroenterology & Hepatology

Molecular Therapy for Obesity and Diabetes Based on a Long-Term Increase in Hepatic Fatty-Acid Oxidation

Josep M. Orellana-Gavalda et al.

HEPATOLOGY (2011)

Article Biochemistry & Molecular Biology

Mitochondrial Carnitine Palmitoyltransferase 1a (CPT1a) Is Part of an Outer Membrane Fatty Acid Transfer Complex

Kwangwon Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Endocrinology & Metabolism

Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo

Heidi A. Parkes et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)