Journal
BIOSCIENCE TRENDS
Volume 16, Issue 2, Pages 158-162Publisher
IRCA-BSSA
DOI: 10.5582/bst.2022.01147
Keywords
bacteriophage therapy; empyema; carbapenem-resistant Pseudomonas aeruginosa; pneumonia; broncho-pleural fistula
Categories
Funding
- National Natural Science Foundation of China [32001038]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB29050501]
- Guangdong Provincial Key Laboratory of Synthetic Genomics [2019B030301006]
- Shenzhen Key Laboratory of Synthetic Genomics [ZDSYS201802061806209]
- Shenzhen Institute of Synthetic Biology Scientific Research Program [JCHZ20200001]
- Shenzhen Third People's Hospital [G2022052]
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This study reports the clinical efficacy of bacteriophage therapy in treating multidrug-resistant P. aeruginosa infection associated with BPF, showing that combined bacteriophage therapy with conventional antibiotics can effectively improve the clinical outcome of the patients.
Pseudomonas aeruginosa is a frequent causative agent of post-pneumonectomy empyema-associated broncho-pleural fistula (BPF) and it has a high mortality rate. In recent years, the therapeutic potential of bacteriophage therapy has recognized anew as antimicrobial resistance increases globally. Studies are increasingly reporting the efficacy and safety of bacteriophage therapy for the treatment of multidrug-resistant bacterial infections. However, the clinical efficacy of bacteriophage therapy in empyema has seldom been studied. The current study reports the authors' experience with bacteriophage therapy for a 68-year-old Chinese man who suffered BPF-associated empyema and pneumonia caused by carbapenem-resistant P. aeruginosa. A personalized lytic pathogen-specific two-phage preparation was administered to the patient continuously for 24 days in combination with conventional antibiotics. The treatment was well-tolerated, resulting in clearance of the pathogen and improvement of the clinical outcome. This experience shows that a combined conventional antibiotic treatment with bacteriophage therapy may be effective at alleviating a multidrug-resistant bacterial infection in BPF-associated empyema.
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