4.6 Article

Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy

Related references

Note: Only part of the references are listed.
Letter Clinical Neurology

Are the UK genetic testing criteria for dementia too exclusive?

Annita Christodoulidou et al.

JOURNAL OF NEUROLOGY (2021)

Review Biochemistry & Molecular Biology

Current and future applications of induced pluripotent stem cell-based models to study pathological proteins in neurodegenerative disorders

Aurelie de Rus Jacquet et al.

Summary: Neurodegenerative disorders arise from cellular mechanism failures, with pathogenic proteins contributing to non-cell autonomous toxicity. Utilizing human in vitro models is crucial for understanding protein aggregation mechanisms in these diseases.

MOLECULAR PSYCHIATRY (2021)

Article Biochemical Research Methods

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

Tasuku Ishida et al.

Summary: PROTACs, or bifunctional degrader molecules, are a novel approach for understanding and treating human diseases by targeting specific proteins for degradation. Advances in nonpeptidic small-molecule E3 ligase ligands, such as VHL and CRBN, have revolutionized the field and led to the development of drug-like PROTACs with powerful degradation capabilities. Ongoing research aims to expand the chemical diversity of PROTACs and explore new approaches for targeted protein degradation.

SLAS DISCOVERY (2021)

Article Medicine, Research & Experimental

A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models

Weijin Wang et al.

Summary: The novel small-molecule PROTAC, C004019, showed promising results in selectively promoting tau protein clearance and improving synaptic and cognitive functions.

THERANOSTICS (2021)

Review Multidisciplinary Sciences

Human pluripotent stem cell-derived models and drug screening in CNS precision medicine

M. Catarina Silva et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2020)

Review Neurosciences

Back to the origins: Human brain organoids to investigate neurodegeneration

I. Faravelli et al.

BRAIN RESEARCH (2020)

Article Chemistry, Multidisciplinary

Optical Control of Small Molecule-Induced Protein Degradation

Yuta Naro et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Editorial Material Chemistry, Medicinal

PROTAC Technology: Opportunities and Challenges

Hongying Gao et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

Review Neurosciences

Tau immunotherapies: Lessons learned, current status and future considerations

L. A. Sandusky-Beltran et al.

NEUROPHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

Katherine A. Donovan et al.

Review Neurosciences

A walk through tau therapeutic strategies

Santosh Jadhav et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML

Matthias Brand et al.

CELL CHEMICAL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

PROTACs: great opportunities for academia and industry

Xiuyun Sun et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)

Review Biochemistry & Molecular Biology

An Overview on the Clinical Development of Tau-Based Therapeutics

Miguel Medina

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Plasticity in binding confers selectivity in ligand-induced protein degradation

Radoslaw P. Nowak et al.

NATURE CHEMICAL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

Lara N. Gechijian et al.

NATURE CHEMICAL BIOLOGY (2018)

Review Clinical Neurology

Tau-targeting therapies for Alzheimer disease

Erin E. Congdon et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Chemistry, Multidisciplinary

Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation

Philipp M. Cromm et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Review Biotechnology & Applied Microbiology

Induced protein degradation: an emerging drug discovery paradigm

Ashton C. Lai et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Biochemistry & Molecular Biology

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

Georg E. Winter et al.

MOLECULAR CELL (2017)

Article Biochemistry & Molecular Biology

Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S. Gadd et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Clinical Neurology

Frontotemporal Dementia

Nicholas T. Olney et al.

NEUROLOGIC CLINICS (2017)

Article Clinical Neurology

Tau passive immunization inhibits not only tau but also Aβ pathology

Chun-ling Dai et al.

ALZHEIMERS RESEARCH & THERAPY (2017)

Article Clinical Neurology

Modeling tau pathology in human stem cell derived neurons

Selina Wray

BRAIN PATHOLOGY (2017)

Review Biochemistry & Molecular Biology

Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway

Ian Collins et al.

BIOCHEMICAL JOURNAL (2017)

Article Clinical Neurology

Tau Positron Emission Tomographic Imaging in Aging and Early Alzheimer Disease

Keith A. Johnson et al.

ANNALS OF NEUROLOGY (2016)

Article Biochemistry & Molecular Biology

Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice

Sumihiro Maeda et al.

EMBO REPORTS (2016)

Article Biochemical Research Methods

Synthesis and quality control of [18F]T807 for tau PET imaging

Daniel P. Holt et al.

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS (2016)

Article Neurosciences

PET Imaging of Tau Deposition in the Aging Human Brain

Michael Schoell et al.

NEURON (2016)

Article Multidisciplinary Sciences

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Kanak Raina et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Biotechnology & Applied Microbiology

Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease

Francesco Panza et al.

BIOMED RESEARCH INTERNATIONAL (2016)

Article Neurosciences

An autoradiographic evaluation of AV-1451 Tau PET in dementia

Val J. Lowe et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)

Review Geriatrics & Gerontology

Phenotypic heterogeneity of monogenic frontotemporal dementia

Alberto Benussi et al.

FRONTIERS IN AGING NEUROSCIENCE (2015)

Review Biochemistry & Molecular Biology

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

Meredith B. Metzger et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

Article Multidisciplinary Sciences

Structure of the DDBI-CRBN E3 ubiquitin ligase in complex with thalidomide

Eric S. Fischer et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

Pharmacological targeting of the pseudokinase Her3

Ting Xie et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs

Philip P. Chamberlain et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

Jan Kroenke et al.

SCIENCE (2014)

Article Clinical Neurology

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

Chun-Fang Xia et al.

ALZHEIMERS & DEMENTIA (2013)

Article Neurosciences

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

David T. Chien et al.

JOURNAL OF ALZHEIMERS DISEASE (2013)

Review Clinical Neurology

What renders TAU toxic

Juergen Goetz et al.

FRONTIERS IN NEUROLOGY (2013)

Article Biochemistry & Molecular Biology

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimers diseases

Giovanni Coppola et al.

HUMAN MOLECULAR GENETICS (2012)

Article Biochemistry & Molecular Biology

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

Najla Kfoury et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

Jing L. Guo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Review Neurosciences

The Many Faces of Tau

Meaghan Morris et al.

NEURON (2011)

Article Clinical Neurology

The heritability and genetics of frontotemporal lobar degeneration

J. D. Rohrer et al.

NEUROLOGY (2009)

Article Biotechnology & Applied Microbiology

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

Anne E. Carpenter et al.

GENOME BIOLOGY (2006)

Review Cell Biology

Tau protein and neurodegeneration

M Goedert

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2004)