Journal
BMC NEPHROLOGY
Volume 23, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12882-022-02775-x
Keywords
Minimal change disease; gastrointestinal stromal tumor; Immunoglobulin E
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This case report describes a patient with MCD associated with GIST and elevated IgE levels. It highlights the importance of considering the possibility of tumor in patients with nephrotic syndrome and elevated IgE levels, when allergic factors are ruled out.
Background Minimal change disease (MCD) is a common cause of the nephrotic syndrome. Several studies have shown an increased incidence of cancer in patients with MCD. However, there are no reports on the association between MCD and gastrointestinal stromal tumor (GIST). Case presentation We report a case of a 66-year-old female with severe nephrotic syndrome and concomitant duodenal GIST. Immunoglobulin test showed a significant increase of IgE levels. The diagnosis of renal histopathology was MCD with subacute tubulointerstitial injury. The combination of preoperative Imatinib mesylate chemotherapy and tumor excision was accompanied by significant remission of proteinuria, and IgE level decreasing, without immunosuppressivetherapy. Conclusions It is the first case report that MCD was associated with GIST and elevated IgE level. Clinically, in patients with elevated IgE level associated with nephrotic syndrome, the possibility of tumor must be taken into account when allergic factors are excluded.
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