New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19-A Large Postmortem and Clinical Analysis

Review Emergency Medicine

Elevated D-dimer levels on admission are associated with severity and increased risk of mortality in COVID-19: A systematic review and meta-analysis

Baris Gungor et al.

Summary: This study found that elevated D-dimer levels on admission are significantly correlated with the severity of COVID-19 pneumonia and may predict mortality in hospitalized patients, indicating it as a potential predictive marker.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2021)

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Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2 RNA in Serum as Predictor of Severe Outcome in Coronavirus Disease 2019: A Retrospective Cohort Study

Karl Hagman et al.

Summary: Detection of SARS-CoV-2 RNA in serum at hospital admission is associated with a higher risk of progression to critical disease and death in COVID-19 patients. Positive results indicate a poorer outcome.

CLINICAL INFECTIOUS DISEASES (2021)

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Letter Critical Care Medicine

Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19

Kevin Roedl et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Anesthesiology

Greater Fibrinolysis Resistance but No Greater Platelet Aggregation in Critically Ill COVID-19 Patients

Christoph Heinz et al.

Summary: The study found significant changes in clot formation and lysis in COVID-19 patients, particularly in increased fibrin contribution to maximum clot firmness and prolongation of lysis time. These findings may contribute to our understanding of the hypercoagulable state in critically ill patients with COVID-19.

ANESTHESIOLOGY (2021)

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Article Medicine, General & Internal

Recommendations on Inpatient Treatment of Patients With COVID-19

Stefan Kluge et al.

Summary: Whether hospital admission is necessary for COVID-19 patients depends on age, comorbidities, respiratory rate, and oxygen saturation. Adequate oxygenation, pharmaceutical prevention of thrombosis, and administration of dexamethasone are crucial elements in the treatment of severe COVID-19 cases.

DEUTSCHES ARZTEBLATT INTERNATIONAL (2021)

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Article Cardiac & Cardiovascular Systems

C-reactive protein and clinical outcomes in patients with COVID-19

Nathaniel R. Smilowitz et al.

Summary: Elevated CRP levels at initial hospital presentation in COVID-19 patients are associated with an increased risk of venous thromboembolism, acute kidney injury, critical illness, and mortality. There is a dose-response relationship between CRP concentration and adverse outcomes, with patients with high levels of both CRP and D-dimer showing the greatest risk of adverse outcomes. Systemic inflammation, as measured by CRP, plays a significant role in predicting clinical outcomes in COVID-19.

EUROPEAN HEART JOURNAL (2021)

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Article Immunology

Association Between Upper Respiratory Tract Viral Load, Comorbidities, Disease Severity, and Outcome of Patients With SARS-CoV-2 Infection

Helena C. Maltezou et al.

Summary: Analysis of 1122 COVID-19 patients revealed that high upper respiratory tract viral load was associated with older age, comorbidities, severe disease (COVID-19), intubation, and mortality, as well as longer stays in the intensive care unit and intubation time. High viral load was also more common in patients with chronic cardiovascular disease, hypertension, chronic pulmonary disease, immunosuppression, obesity, and chronic neurological disease.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Review Critical Care Medicine

Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019 A Systematic Review and Meta-analysis

David Jimenez et al.

Summary: The pooled incidence of VTE and bleeding among hospitalized patients with COVID-19 was 17.0% and 7.8% respectively. Factors such as routine screening, critical illness, inclusion of distal DVT and subsegmental PE, and prospective studies were associated with higher rates of VTE. The incidence of bleeding events was sensitive to escalated doses of anticoagulants and the nature of data collection.

CHEST (2021)

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Article Infectious Diseases

High prevalence of occult thrombosis in cases of mild/moderate COVID-19

Budong Chen et al.

Summary: This study evaluated the incidence of thromboembolism in mild/moderate cases of COVID-19 and found that 82.6% of the cases had VTE, mainly distal limb thrombosis.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Hematology

Clinical characteristics and risk factors for symptomatic venous thromboembolism in hospitalized COVID-19 patients: A multicenter retrospective study

Jun-Ying Li et al.

Summary: The study found that severe and non-severe hospitalized COVID-19 patients have nearly 6 times and 3 times higher odds of developing symptomatic VTE compared to general medical inpatients. VTE commonly develops at a median of 21 days after symptom onset and independent risk factors include advancing age, cancer, longer interval from symptom onset to admission, lower fibrinogen, and higher D-dimer levels.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Critical Care Medicine

Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: A multicentric study in Germany

Kevin Roedl et al.

Summary: This study investigated the characteristics and outcomes of critically ill patients with COVID-19 requiring ICU admission and MV. Among 223 patients, the survival rate to ICU discharge was 65%, and it was 56% among patients requiring MV. Patients showed a high rate of septic complications during their ICU stay.

AUSTRALIAN CRITICAL CARE (2021)

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Article Multidisciplinary Sciences

Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases

Antonia Fitzek et al.

Summary: This study conducted a systematic review of 735 SARS-CoV-2-associated deaths in Hamburg, Germany from March to December 2020, highlighting that the majority of COVID-19 deaths were in older individuals with multiple comorbidities. The research underscores the importance of mortality surveillance and postmortem examinations.

SCIENTIFIC REPORTS (2021)

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Article Medicine, General & Internal

Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19 The HEP-COVID Randomized Clinical Trial

Alex C. Spyropoulos et al.

Summary: Therapeutic-dose low-molecular-weight heparin reduces major thromboembolism and death in high-risk inpatients with COVID-19, with no significant effect observed in critically ill patients.

JAMA INTERNAL MEDICINE (2021)

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Article Medicine, General & Internal

Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit The INSPIRATION Randomized Clinical Trial

Parham Sadeghipour et al.

Summary: This study compared the effect of intermediate-dose and standard prophylactic anticoagulation on a composite outcome among COVID-19 patients admitted to the ICU. The results showed no significant difference between the two groups in terms of thrombotic events, ECMO therapy, or mortality within 30 days. The study does not recommend routine use of intermediate-dose prophylactic anticoagulation in unselected ICU patients with COVID-19.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Immunology

SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients

Fabian Heinrich et al.

Summary: The study found that in critically ill COVID-19 patients, blood SARS-CoV-2 RNA load can serve as a prognostic factor, with significantly higher levels in non-survivors upon ICU admission and a higher probability of blood RNA clearance failure. Blood RNA load represents an important independent predictor of outcome for critically ill COVID-19 patients, with a higher impact on survival compared to respiratory tract SARS-CoV-2 RNA loads.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Article Critical Care Medicine

Pulmonary Thrombosis and Thromboembolism in COVID-19

Hooman D. Poor

Summary: COVID-19 is associated with a significantly increased risk of pulmonary thrombosis, possibly driven by a hypercoagulable state and vascular injury. Some patients with COVID-19 may have hypoxemia that is disproportionate to impairment in lung compliance. Diagnosing PE in patients with COVID-19 can be challenging, leading many hospitals to implement aggressive anticoagulation protocols.

CHEST (2021)

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Article Hematology

Standard prophylactic versus intermediate dose enoxaparin in adults with severe COVID-19: A multi-center, open-label, randomized controlled trial

Usha S. Perepu et al.

Summary: In hospitalized adults with severe COVID-19, standard prophylactic dose and intermediate dose enoxaparin did not significantly differ in preventing death or thrombosis at 30 days. The occurrence of arterial or venous thrombosis was slightly higher than the rate of major bleeding.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Medicine, General & Internal

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial

Renato D. Lopes et al.

Summary: In hospitalized COVID-19 patients with elevated D-dimer concentration, in-hospital therapeutic anticoagulation with rivaroxaban or enoxaparin followed by rivaroxaban to day 30 did not improve clinical outcomes and increased bleeding compared with prophylactic anticoagulation. Therapeutic-dose rivaroxaban and other direct oral anticoagulants should be avoided in these patients without an evidence-based indication for oral anticoagulation.

LANCET (2021)

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Article Medicine, General & Internal

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

Ewan C. Goligher et al.

Summary: In critically ill patients with Covid-19, initial therapeutic-dose anticoagulation did not result in improved survival rates or fewer days requiring cardiovascular or respiratory organ support compared to usual-care pharmacologic thromboprophylaxis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

C-reactive protein and clinical outcomes in patients with COVID-19

Nathaniel R. Smilowitz et al.

Summary: Elevated CRP levels upon hospital admission in COVID-19 patients are associated with increased risks of VTE, AKI, critical illness, and mortality, suggesting a crucial role of systemic inflammation in the clinical course of COVID-19.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

2019 ESC Guidelines for the dignosis and management of acute pulmonary embolism development Toed in colaboration with the European Respiratory Society (ERS)

Stavros Konstantinides et al.

EUROPEAN HEART JOURNAL (2020)

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Article Medicine, General & Internal

Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome Results From a Prospective, Single-Center, Clinicopathologic Case Series

Sigurd F. Lax et al.

ANNALS OF INTERNAL MEDICINE (2020)

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Article Medicine, General & Internal

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

Dominic Wichmann et al.

ANNALS OF INTERNAL MEDICINE (2020)

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Review Critical Care Medicine

Coagulopathy of Coronavirus Disease 2019

Toshiaki Iba et al.

CRITICAL CARE MEDICINE (2020)

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Letter Respiratory System

Pulmonary embolism in patients with COVID-19 pneumonia

Florian Bompard et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Article Critical Care Medicine

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study

Julie Helms et al.

INTENSIVE CARE MEDICINE (2020)

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Article Medicine, General & Internal

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

Safiya Richardson et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

Giacomo Grasselli et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Critical Care Medicine

Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals: an observational study

Christian Karagiannidis et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Medicine, Legal

Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany

Carolin Edler et al.

INTERNATIONAL JOURNAL OF LEGAL MEDICINE (2020)

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Letter Medicine, General & Internal

Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System

Seda Bilaloglu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Letter Infectious Diseases

Viral dynamics in mild and severe cases of COVID-19

Yang Liu et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Respiratory System

Elevated D-dimers and lack of anticoagulation predict PE in severe COVID-19 patients

Basile Mouhat et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Article Hematology

Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis

F. A. Klok et al.

THROMBOSIS RESEARCH (2020)

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Review Hematology

Thrombosis risk associated with COVID-19 infection. A scoping review

Fatimah Al-Ani et al.

THROMBOSIS RESEARCH (2020)

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Article Hematology

Therapeutic versus prophylactic anticoagulation for severe COVID-19: A randomized phase II clinical trial (HESACOVID)

Anna Cristina Bertoldi Lemos et al.

THROMBOSIS RESEARCH (2020)

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Article Critical Care Medicine

Protracted viral shedding and viral load are associated with ICU mortality in Covid-19 patients with acute respiratory failure

L. Bitker et al.

ANNALS OF INTENSIVE CARE (2020)

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Article Hematology

Challenges in treatment of patients with acute leukemia and COVID-19: a series of 12 patients

Susanne Ghandili et al.

BLOOD ADVANCES (2020)

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Article Critical Care Medicine

Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

Jesus F. Bermejo-Martin et al.

CRITICAL CARE (2020)

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Review Medicine, General & Internal

Thromboembolism risk of COVID-19 is high and associated with a higher risk of mortality: A systematic review and meta-analysis

Mahmoud B. Malas et al.

ECLINICALMEDICINE (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 viral load is associated with increased disease severity and mortality

Jesse Fajnzylber et al.

NATURE COMMUNICATIONS (2020)

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Venous Thromboembolism Prophylaxis: A Narrative Review With a Focus on the High-Risk Critically Ill Patient

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JOURNAL OF INTENSIVE CARE MEDICINE (2019)

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Venous thromboembolism in the ICU: main characteristics, diagnosis and thromboprophylaxis

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CRITICAL CARE (2015)

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New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19-A Large Postmortem and Clinical Analysis

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