4.6 Article

TBK1 Mediates Innate Antiviral Immune Response against Duck Enteritis Virus

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Keywords: Duck enteritis virus Pathogenicity Viral load TLRs MHC class-I Interferon-α Th1cytokines

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Summary: This comprehensive study examines the pathogenicity and immune response of White Pekin ducklings infected with an Indian isolate of duck enteritis virus (DEV). The study reveals that the virus is highly pathogenic and spreads throughout the body, particularly in the spleen and liver, causing severe pathological damage and 100% mortality. The analysis of immune gene expression profiles suggests the upregulation of proinflammatory cytokines and immune signaling pathways, indicating the activation of innate and adaptive immune responses against the virus.

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