4.6 Article

Isolation and Genomic Characterization of SARS-CoV-2 Omicron Variant Obtained from Human Clinical Specimens

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Elucidating the role of N440K mutation in SARS-CoV-2 spike - ACE-2 binding affinity and COVID-19 severity by virtual screening, molecular docking and dynamics approach

Malathi Kullappan et al.

Summary: COVID-19 has become a global public health concern. The N440K variant, observed in the second wave in South India, affects the transmission and severity of the disease. This variant is capable of escaping antibody neutralization, increasing the risk of reinfection. Molecular modeling studies revealed that the wild type virus binds more tightly and stably to the receptor.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2023)

Article Multidisciplinary Sciences

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron

Huiping Shuai et al.

Summary: The Omicron variant of SARS-CoV-2 shows reduced replication ability in human cells and attenuated pathogenicity in mice compared with the wild-type strain and other variants. It has lower efficiency in using TMPRSS2 and causes the lowest reduction in body weight and mortality rate among the tested strains.

NATURE (2022)

Article Biochemistry & Molecular Biology

An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

Laura A. VanBlargan et al.

Summary: The emergence of the B.1.1.529 Omicron variant raises concerns about the efficacy of antibody countermeasures. This study shows that some of the antibodies currently in clinical use may lose their ability to neutralize the Omicron variant.

NATURE MEDICINE (2022)

Article Infectious Diseases

Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity, and differences in growth profile

Nathalie Wurtz et al.

Summary: The study tested 4 locally isolated strains of SARS-CoV-2 on 34 cell lines commonly used for isolating human pathogenic microorganisms, finding that 7 cell lines were able to support virus replication. Results indicate that there are differences in cytopathogenic effects and multiplication abilities in cells with different strains.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2021)

Letter Immunology

First isolation of SARS-CoV-2 from clinical samples in India

Prasad Sarkale et al.

INDIAN JOURNAL OF MEDICAL RESEARCH (2020)

Letter Immunology

Development of in vitro transcribed RNA as positive control for laboratory diagnosis of SARS-CoV-2 in India

Manohar Lal Choudhary et al.

INDIAN JOURNAL OF MEDICAL RESEARCH (2020)