Journal
CANCER LETTERS
Volume 356, Issue 2, Pages 251-262Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.02.008
Keywords
Cancer; Metabolism; Natural compounds; mTOR
Categories
Funding
- Action LIONS Vaincre le Cancer
- Recherche Cancer et Sang foundation
- Recherches Scientifiques Luxembourg asbl
- Een Haerz fir Kriibskrank Kanner association
- Action Lions Vaincre le Cancer Luxembourg, Televie Luxembourg
- National Research Foundation (NRF), MEST of Korea for Tumor Microenvironment Global Core Research Center (GCRC) Grant [2012-0001184]
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Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter of a metabolic network controlling upstream and downstream modulation of these same genes. Natural compounds represent a source of anti-cancer molecules with chemopreventive and therapeutic properties. This review describes selected pathways and genes orchestrating the metabolic reprogramming and discusses the potential of natural compounds to target oncogenic metabolic aberrations. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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