Related references
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Review
Clinical Neurology
Josef Finsterer
Summary: This review discusses the neurological side effects of SARS-CoV-2 vaccines, focusing on headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis, which healthcare professionals should be vigilant about.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Review
Emergency Medicine
Razieh Sadat Mousavi-Roknabadi et al.
Summary: This systematic scoping review assessed the epidemiology, clinical findings, patient management, causes, and recommendations for prevention or reduction of methanol poisoning during the COVID-19 pandemic. After searching and evaluating relevant studies, the findings were summarized in four categories. The results indicate that methanol poisoning poses significant challenges during the COVID-19 pandemic.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Laura Vangeel et al.
Summary: Remdesivir and its parent nucleoside, molnupiravir and its parent nucleoside, and the viral protease inhibitor nirmatrelvir have equipotent antiviral activity against the ancestral SARS-CoV2 strain and the variants of concern including Omicron.
ANTIVIRAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zheng Yao Low et al.
Summary: Ivermectin, an FDA-approved drug traditionally used for parasitic infections, has shown antiviral potential in previous in vitro studies. With the recent COVID-19 pandemic, there is growing interest in repurposing Ivermectin to combat SARS-CoV-2. Multiple studies have demonstrated its effectiveness in inhibiting viral proteins and reducing cytokine storms, making it a strong candidate for clinical trials against COVID-19.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Medicine, Research & Experimental
Kadalraja Raghavan et al.
Summary: This pilot clinical study demonstrated the beneficial effects of beta glucans derived from black yeast Aureobasidium pullulans on cytokine storm and coagulopathy biomarkers in COVID-19 patients. The combination of AFO-202 and N-163 beta glucans showed significant improvements in D-Dimer and IL-6 levels, as well as CD4+ and CD8+ T cell count. Larger multicentric clinical studies are recommended to further validate these findings for potential use in managing COVID-19 and long COVID-19 syndrome.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Yasmine M. Elamir et al.
Summary: A trial investigating the use of calcitriol in hospitalized COVID-19 patients showed improvement in oxygenation and higher percentage of patients discharged without needing oxygen supplementation in the calcitriol group. Additionally, patients in the calcitriol group had shorter hospital stays. These results suggest potential benefits of calcitriol therapy and support the need for larger randomized trials.
Editorial Material
Infectious Diseases
Elizabeth Miller
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Editorial Material
Chemistry, Multidisciplinary
Chaoqi Wang et al.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Article
Infectious Diseases
Dora Buonfrate et al.
Summary: This study assessed the safety and efficacy of high-dose ivermectin in reducing viral load in individuals with early SARS-CoV-2 infection. The results showed that high-dose ivermectin was safe but did not reduce viral load effectively.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Biochemistry & Molecular Biology
Purva Asrani et al.
Summary: COVID-19, caused by the novel coronavirus SARS-CoV-2, has led to a global pandemic, with the development and distribution of vaccines being crucial. This review article categorizes and analyzes potential drugs for COVID-19, highlighting the need for effective therapeutic interventions for those who are not vaccinated or susceptible to emerging SARS-CoV-2 variant strains.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Letter
Clinical Neurology
Seungyon Koh et al.
JOURNAL OF CLINICAL NEUROLOGY
(2022)
Article
Chemistry, Physical
Ola A. El-Gammal et al.
Summary: This study investigates the properties of a novel Schiff base and its complexes with Co(II), Ni(II), and Cu(II) metals using various analysis methods. The research covers structural characterization, thermodynamic properties, DNA binding, antioxidant activity, and antibacterial action. The potential of the compound in combating COVID-19 and prostate cancer is evaluated through its interaction with the SARS-CoV-2 main protease.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Neurosciences
Patrick Moore et al.
Summary: The COVID-19 pandemic has led to millions of deaths worldwide, with the potential for neurological complications caused by the virus. These complications may stem from the severity of systemic infection, direct viral invasion of the central nervous system, and possible immune mediated mechanisms.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Medicine, General & Internal
Arabella S. Stuart et al.
Summary: The study investigated the mixed use of different COVID-19 vaccines within the same schedule, showing that in certain conditions, heterologous vaccination can achieve similar immunogenicity to homologous vaccination, facilitating rapid global vaccine deployment.
Review
Biochemistry & Molecular Biology
Alessia Catalano et al.
Summary: Multidrug resistance, including resistance to anticancer agents and antimicrobial drugs, is a significant concern in public health. The widespread use of antibiotics has led to the emergence of pathogenic bacteria resistant to multiple drugs, and the ongoing COVID-19 pandemic may worsen antimicrobial resistance. Nanodrug delivery systems have shown promise in overcoming resistance.
Editorial Material
Clinical Neurology
Abdul Mannan Baig
Summary: Neurological deficits caused by COVID-19 were first reported in early 2020 and continue to be a topic of interest among neurologists and healthcare professionals worldwide. Two new studies highlight the frequency and expected increase in morbidity and mortality burden in both the acute and chronic phases of the disease.
NATURE REVIEWS NEUROLOGY
(2022)
Letter
Psychiatry
William D. S. Killgore et al.
PSYCHIATRY RESEARCH
(2022)
Review
Environmental Sciences
Sidra Ghazali Rizvi et al.
Summary: Antimicrobial resistance is becoming a serious concern due to overuse of antibiotics, exacerbated by the increase in global antibiotic usage during the COVID-19 pandemic. This has led to higher concentrations of residual antibiotics in wastewater, posing a threat to natural water bodies. Urgent measures are needed to curb antibiotic usage and improve wastewater treatment to efficiently remove residual contaminants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Nutrition & Dietetics
Amir Vahedian-Azimi et al.
Summary: This systematic review investigates the efficacy of curcumin supplementation in COVID-19 patients. The findings suggest that curcumin supplementation can significantly decrease symptoms, duration of hospitalization, and deaths. It also shows that curcumin helps balance pro-inflammatory and anti-inflammatory factors, improving the cytokine storm effect. Overall, curcumin supplementation may offer a safe and effective option for improving COVID-19 disease outcomes.
Article
Nutrition & Dietetics
Tom D. Thacher
Summary: Laboratory evidence supports the benefits of vitamin D in COVID-19, with supplementation linked to reduced respiratory infection risk. Most clinical studies are observational, with a key limitation being confounding factors. While observational studies show potential benefits, randomized controlled trials are needed to confirm the effectiveness of vitamin D supplementation in COVID-19 patients.
Article
Cell Biology
Tonino Alonzi et al.
Summary: This study found that the aminothiol cysteamine and its oxidation product cystamine have antiviral effects against SARS-CoV-2 and can decrease viral production. Additionally, these compounds have immune-modulatory effects and can reduce the production of specific immune factors in COVID-19 patients. These findings provide a potential rationale for the use of cysteamine and cystamine as a novel therapy for COVID-19.
Article
Immunology
Tina Y. Poussaint et al.
Summary: A 12-year-old boy developed acute encephalopathy and other symptoms after receiving the COVID-19 vaccine, suggesting a potential immune-related reaction. After treatment, the boy recovered and his symptoms disappeared.
Article
Infectious Diseases
Jessica Ceramella et al.
Summary: Schiff bases have a wide range of applications in various fields and their conjugation with chitosan can enhance chitosan's antibacterial activity. The use of Schiff base nanoparticles can also improve their antimicrobial effects.
Article
Biochemistry & Molecular Biology
Nousheen Bibi et al.
Summary: COVID-19 vaccine will help attenuate the disease progression rates, but its distribution may pose challenges and delays. Repurposed drugs against SARS-CoV-2 could be an attractive strategy, especially in poorly-resourced countries. This study conducted virtual screening of broad-spectrum antiviral agents against key proteins of SARS-CoV-2, identifying drugs with high binding affinities to multiple targets.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Dermatology
Devon E. McMahon et al.
Summary: This study investigated histopathologic features and clinical correlations of cutaneous reactions after COVID-19 vaccination, proposing the concept of V-REPP (vaccine-related eruption of papules and plaques) and 12 other reaction patterns. Despite limitations in available biopsy reports, the research provided new insights into skin reactions following vaccination.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
H. Mehta et al.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Chemistry, Applied
Misbaudeen Abdul-Hammed et al.
Summary: The current research utilized virtual screening to study 57 isolated phytochemicals against the SARS-CoV-2 main protease, identifying several potential inhibitors with good bioactivity and drug-likeness properties. These compounds could be promising candidates for the development of new therapeutic agents against SARS-CoV-2.
NATURAL PRODUCT RESEARCH
(2022)
Review
Virology
Chiranjib Chakraborty et al.
Summary: The study discusses the emergence of alarming SARS-CoV-2 variants globally, highlighting key properties, mutations, and clinical characteristics of both variant of concern (VOC) and variant of interest (VOI) variants. The comprehensive review offers updated information on these newly appearing variants to aid researchers in formulating strategies to control the COVID-19 pandemic.
REVIEWS IN MEDICAL VIROLOGY
(2022)
Review
Virology
Timotius Ivan Hariyanto et al.
Summary: Vitamin D supplementation may have beneficial effects on Covid-19 outcomes, reducing ICU admission rate, need for mechanical ventilation, and mortality. Additionally, the associations were found to be influenced by age.
REVIEWS IN MEDICAL VIROLOGY
(2022)
Article
Plant Sciences
Pulok K. Mukherjee et al.
Summary: This review highlights the potential role of herbs and their derivatives in inhibiting the SARS-CoV-2 virus and managing post-COVID-19 complications. Studies have shown that plant-derived phytochemicals can prevent viral infections and help overcome various post-COVID complications. The research explored mechanistic approaches of herbal medicines and their components in addressing antiviral effects and post-COVID complications, suggesting the potential of herbal remedies in combating COVID-19.
Article
Biochemistry & Molecular Biology
Mohammad Mahdi Nejadi Babadaei et al.
Summary: SARS-CoV-2 is the causative agent of a severe respiratory illness that has caused widespread human infections and deaths in many countries since late 2019. Although there is no FDA-approved drug specifically for SARS-CoV-2, antiviral agents like Remdesivir are being evaluated for their potential effectiveness. This review focuses on the application of Remdesivir against different coronaviruses and discusses its potential in preclinical trials for preventing SARS-CoV-2 infections.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Endocrinology & Metabolism
F. M. Panfili et al.
Summary: The COVID-19 pandemic requires urgent therapeutic interventions, especially for vulnerable populations such as elderly males. Vitamin D has shown promising immunomodulatory effects and may play a role in the prevention and treatment of SARS-CoV-2 infection in both adults and children.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Review
Plant Sciences
Susmit Mhatre et al.
Summary: This study reviewed the antiviral activities of tea polyphenols and their interactions with SARS-CoV-2, indicating significant potential in the treatment and prophylaxis of COVID-19. In particular, theaflavin-3,3'-digallate (TF3) showed significant binding with viral receptors, highlighting the efficacy of tea polyphenols against COVID-19.
Review
Infectious Diseases
Daniel Echeverria-Esnal et al.
Summary: Azithromycin shows antiviral and immunomodulatory properties, which may be beneficial in treating COVID-19. However, evidence for its use is scarce and of low quality.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Article
Biology
Miloslav Klugar et al.
Summary: This study focused on reporting the short-term side effects following COVID-19 vaccination among German healthcare workers, comparing mRNA-based and viral vector-based vaccines. Most side effects resolved within 1-3 days post-vaccination, indicating promising safety profiles for both vaccine types.
Review
Integrative & Complementary Medicine
Andrea D. Fuzimoto
Summary: Artemisia annua and its compounds show potential in inhibiting SARS-CoV-2 by impeding viral replication and transmission through various pathways. Studies suggest that Artemisia annua may have a synergistic effect in inhibiting SARS-CoV-2 when combined with other drugs, and may also modulate the host immune response to better combat the infection.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Letter
Infectious Diseases
Xingwang Jia et al.
JOURNAL OF INFECTION
(2021)
Article
Sport Sciences
Kayvan Khoramipour et al.
Summary: In the midst of the COVID-19 pandemic, maintaining physical activity is crucial for promoting health, especially during times of social isolation. Individuals with specific health conditions may require tailored exercise programs. Additionally, the intake of vitamins D and C, omega-3 fatty acids, and regular consumption of fruits and vegetables can aid in supporting the immune system.
JOURNAL OF SPORTS SCIENCES
(2021)
Review
Chemistry, Medicinal
Giuseppe Derosa et al.
Summary: COVID-19, caused by novel coronavirus (SARS-CoV-2), was first detected in Wuhan City, China. Quercetin has the potential to inhibit virus replication and possesses anti-inflammatory and thrombin-inhibitory actions.
PHYTOTHERAPY RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Tobias Goris et al.
Summary: This study reviews the antiviral activity of flavonoids specific for coronaviruses and the results of computational studies targeting specific coronaviral proteins. It aims to use synthetic biology to enable the fast and customized production of valuable antiviral flavonoids by applying the latest concepts of division of labor in microbial community approaches.
MICROBIAL BIOTECHNOLOGY
(2021)
Letter
Medicine, General & Internal
Justine Perez et al.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Erik De Clercq
Summary: Remdesivir is the only antiviral drug formally approved by the US FDA for the treatment of Covid-19. Its key structural features and mode of action have been well established, but further optimization in clinical application is needed in terms of dosage, timing, route of administration, and potential combinations with other drugs for efficacy evaluation.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Hui Chen et al.
Summary: The study found that corticosteroid therapy was not significantly associated with 28-day mortality in critically ill patients with COVID-19, but showed significant survival benefits in patients with the hyperinflammatory phenotype.
Review
Pharmacology & Pharmacy
Parastoo Tarighi et al.
Summary: The latest COVID-19 pandemic has no conventional treatment or vaccine, leading to investigations on the repositioning of existing drugs as potential therapeutic options. Many drugs are currently undergoing clinical trials for efficacy and safety in treating COVID-19.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Infectious Diseases
Divakar Sharma et al.
Summary: In the current global scenario, COVID-19 caused by SARS-CoV-2 remains a major clinical and public health issue with no approved efficient therapeutics. FDA approved broad-spectrum drugs/molecules are being repurposed in clinical trials for potential management of the pandemic. Expert opinions suggest repurposing pathogen-centric, host-centric, dual sword, and combinatorial drugs as potential options for effective management of COVID-19 patients.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Editorial Material
Medicine, General & Internal
Maria Deloria Knoll et al.
Article
Biochemical Research Methods
Ying Song et al.
Summary: The emergence of COVID-19 has led to the urgent need for accurate diagnoses through CT scans. Researchers have developed a deep learning-based CT diagnosis system to accurately identify COVID-19 patients, achieving high levels of accuracy and reliability.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2021)
Review
Immunology
Vincent Feuillet et al.
Summary: Most individuals infected with SARS-CoV-2 have mild symptoms, possibly due to their ability to rapidly produce interferons, while a minority of infected individuals with chronic inflammatory conditions lack this early efficient response.
TRENDS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jean-Baptiste Lascarrou et al.
Summary: In a multicenter case-control study on COVID-19 patients, it was found that patients with symptoms of headache and fatigue/malaise were more likely to have a false-negative result in their first RT-PCR test. Conversely, patients with elevated platelet and C-reactive protein levels were at a higher risk of a false-negative first RT-PCR test result. This highlights the importance of evaluating strategies involving serial RT-PCR testing for COVID-19 diagnosis.
SCIENTIFIC REPORTS
(2021)
News Item
Medicine, General & Internal
Elisabeth Mahase
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Critical Care Medicine
Jing Zhang et al.
Summary: In this trial, high-dose vitamin C infusion did not improve IMVFD28 for patients with severe COVID-19, but may have a potential benefit in oxygenation.
ANNALS OF INTENSIVE CARE
(2021)
Review
Chemistry, Multidisciplinary
Alessia Catalano et al.
Summary: Diarylurea is a crucial scaffold in medicinal chemistry, found in various heterocyclic compounds with properties such as antithrombotic, antimalarial, antibacterial, and anti-inflammatory. Recent literature has reported diarylureas as inhibitors of serine-threonine kinase or tyrosine kinase. The first diarylurea to be marketed as an anticancer agent was sorafenib, with others following suit. This review explores the progress made in the past decade in developing new diarylureas as anticancer agents.
APPLIED SCIENCES-BASEL
(2021)
Article
Public, Environmental & Occupational Health
Billy J. Quilty et al.
Summary: The study suggests that testing contacts and reducing quarantine duration can be effective in limiting onward transmission of COVID-19, with potential for substantial reduction in the length of quarantine with a small excess in transmission risk. Adherence to quarantine and self-isolation, along with decreasing test and trace delays, are key factors in improving the effectiveness of these strategies. Further research is needed to evaluate the costs and benefits of implementing such strategies as policy.
LANCET PUBLIC HEALTH
(2021)
Review
Biochemistry & Molecular Biology
Olivia G. Camp et al.
Summary: Recent studies have found a correlation between COVID-19 and the cytokine storm, which leads to excessive production of reactive oxygen species. Melatonin, a potent MPO inhibitor, has been proposed as a therapeutic agent for COVID-19 due to its anti-inflammatory, anti-oxidative properties.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Review
Infectious Diseases
Alessia Catalano et al.
Summary: Antimicrobials have played a significant role in advancing medical treatments, but the emergence of antimicrobial resistance poses challenges in treating infectious diseases. The identification of new coronavirus variants, such as the one in the UK, underscores the urgent need for safe and potent antimicrobials and antivirals. Efforts to develop multitarget therapeutic strategies using compounds like diarylureas are seen as promising for combating new pandemic events.
Review
Infectious Diseases
Nicholas Rebold et al.
Summary: This article reviews the main therapies utilized for COVID-19 and drugs under investigation, with dexamethasone being the only one showing a mortality benefit in randomized controlled trials. Overall, the summarized evidence for other therapies shows limited positive results, highlighting the importance of a broad summary of evidence for clinicians to make safer treatment decisions.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Medicine, General & Internal
Joseph Heskin et al.
Article
Infectious Diseases
Talha Burki
LANCET INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Elie Dolgin
News Item
Multidisciplinary Sciences
Heidi Ledford
Review
Medicine, Research & Experimental
Marilena Vlachou et al.
Summary: Melatonin, known for its neuroprotective and cardioprotective properties, also plays crucial roles in regulating biological rhythms, sleep, metabolism, and immune response. Recent clinical trials have shown its potential as an adjuvant treatment for COVID-19, rekindling interest in the scientific community.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Editorial Material
Medicine, General & Internal
John R. Mascola et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Medicine, General & Internal
Edward H. Livingston et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Mark Szendrey et al.
Summary: This study investigated the effects of chloroquine, hydroxychloroquine, azithromycin, and remdesivir on cardiac potassium channels. Chloroquine and hydroxychloroquine were found to block hERG channels, while azithromycin and remdesivir did not. These findings provide insights into potential cardiac safety concerns of COVID-19 treatment drugs.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Review
Nutrition & Dietetics
Kuljit Singh et al.
Summary: COVID-19, caused by SARS-CoV-2, is a global pandemic with ongoing research into vaccines and antiviral drug regimens. Probiotics, as live microorganisms, have shown promising potential in preventing respiratory viral infections and boosting immunity.
NUTRITION RESEARCH
(2021)
Article
Environmental Sciences
Candice L. Swift et al.
Summary: The study compared wastewater samples from two different wastewater treatment plants in South Carolina, USA, and found that wastewater surveillance can provide earlier community-level detection and detect specific mutations associated with variants of the SARS-CoV-2 virus.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Nutrition & Dietetics
Nitida Pastor et al.
Summary: The trend of using phytonutrients and nutraceuticals to impact immune health has increased recently, as these substances may have immunomodulating effects that can be used for prevention and treatment of viral diseases, including COVID-19. Research has identified certain flavonoids as potential adjuvant therapeutic agents against viral infections, particularly COVID-19.
News Item
Medicine, General & Internal
Elisabeth Mahase
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Gytis Dudas et al.
Summary: The emergence and spread of a new potential SARS-CoV-2 variant of interest, B.1.620, is described. This lineage, first identified in Lithuania, has established local transmission in Europe on multiple occasions and likely emerged in Central Africa.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Domenico Iacopetta et al.
Summary: Schiff bases, named after Hugo Schiff, are highly reactive organic compounds widely used in various applications such as pigments, dyes, catalysts, intermediates in organic synthesis, and polymer stabilizers. They are known for their diverse biological activities, including antitumor properties, as well as their ability to form complexes with metals. The complexes of Schiff bases with metals have shown interesting antitumor activities.
APPLIED SCIENCES-BASEL
(2021)
Correction
Microbiology
Andrew Rambaut et al.
NATURE MICROBIOLOGY
(2021)
Article
Medical Laboratory Technology
Kotaro Aoki et al.
Summary: The study evaluated the performance of the combination of RT-PCR and IgG assay for diagnosing COVID-19. Results showed that sensitivity increased with the number of days after symptom onset, while specificity remained high across different case groups.
ANNALS OF LABORATORY MEDICINE
(2021)
News Item
Medicine, General & Internal
Owen Dyer
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Infectious Diseases
Keivan Ranjbar et al.
Summary: The study demonstrated that methylprednisolone was more effective than dexamethasone in hospitalized hypoxic COVID-19 patients, with better clinical status, shorter hospital stay, and lower need for a ventilator in the intervention group.
BMC INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Jerome Montnach et al.
Summary: Through the O'Hara-Rudy computer model, the study evaluates the arrhythmogenic potential of clinical factors in COVID-19 patients that can further alter repolarization, in addition to hydroxychloroquine and azithromycin, such as tachycardia, hypokalaemia, and subclinical to mild Long QT syndrome. The results show that hydroxychloroquine and azithromycin have little impact on QT duration and do not induce any substrate prone to arrhythmia in COVID-19 patients with normal cardiac repolarization reserve. However, in conditions with reduced repolarization reserve, there may be larger electrocardiogram impairments, as seen with dofetilide.
Review
Biochemistry & Molecular Biology
Domenico Iacopetta et al.
Summary: Triclocarban, a polychlorinated aromatic antimicrobial agent, has been widely used in various products for over 50 years, but concerns about its endocrine disruptive properties have led to a ban by the U.S. Food and Drug Administration in hand and body washes. Efforts are now being made to find alternative antimicrobial compounds.
Article
Multidisciplinary Sciences
Graham Lawton
Review
Multidisciplinary Sciences
Sasha Peiris et al.
Summary: The main pathological findings of severe/fatal COVID-19 infection include diffuse alveolar damage (DAD), changes related to coagulopathy and/or hemodynamic compromise. Additionally, myocarditis may be associated with sequelae according to the observed organ damage.
Review
Endocrinology & Metabolism
Awadhesh Kumar Singh et al.
Summary: Molnupiravir has shown significant benefits in reducing hospitalization or death in mild COVID-19 cases, making it a potential important tool in combating SARSCoV-2. However, its efficacy in moderate to severe COVID-19 remains uncertain, requiring further studies for clarification.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Letter
Medicine, Research & Experimental
Mojtaba Yousefi et al.
Summary: This study aims to investigate the efficacy of pomegranate juice on inflammatory biomarkers in patients with COVID-19. It is a randomized, double-blind, placebo-controlled clinical trial designed to understand the effects of pomegranate juice on patients with COVID-19.
Article
Medicine, General & Internal
Laurens Liesenborghs et al.
Summary: Itraconazole showed in vitro activity against SARS-CoV-2, but did not demonstrate efficacy in hamster models and clinical trials.
Review
Microbiology
Ronan Lordan et al.
Summary: This review critically evaluates the evidence surrounding the potential prophylactic and therapeutic value of dietary supplements and nutraceuticals for COVID-19. While nutritional status plays a significant role in patient outcomes and certain products like vitamin D may hold promise, further research is necessary to formulate evidence-based recommendations. Sales of these products have surged during the pandemic, but more research is needed to determine their efficacy against SARS-CoV-2 and COVID-19.
Article
James A Cave et al.
Drug and Therapeutics Bulletin
(2021)
Article
Biology
Pradeep Kumar Chaudhary et al.
Summary: This study introduces a method based on Fourier-Bessel series expansion for diagnosing pneumonia caused by COVID-19. By decomposing chest X-ray images and chest computer tomography images into sub-band images and training with deep learning models, rapid diagnosis of COVID-19 patients is achieved.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Review
Substance Abuse
Rose A. Schmidt et al.
Summary: This systematic review examined the early impact of COVID-19 on substance use, finding that certain segments of the population increased their alcohol use early on in the pandemic and may be at greater risk of harm, requiring additional services or interventions.
DRUG AND ALCOHOL DEPENDENCE
(2021)
News Item
Multidisciplinary Sciences
T. V. Padma
Editorial Material
Biochemistry & Molecular Biology
Brandon Malone et al.
Summary: Molnupiravir disrupts the accuracy of SARS-CoV-2 genome replication and prevents viral propagation by fostering error accumulation, a process known as 'error catastrophe'.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2021)
Article
Medicine, General & Internal
S. J. Thomas et al.
Summary: BNT162b2 vaccine remains highly effective and safe over the course of 6 months post-vaccination, with efficacy rates ranging from 86% to 100% across different demographics and risk factors for Covid-19. The vaccine also shows a high efficacy against severe disease, with particularly promising results observed in South Africa against the B.1.351 variant.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Virology
Ahlam Chaqroun et al.
Summary: The genetically variable SARS-CoV-2 virus has led to the emergence of different variants that affect transmissibility and immune escape. Further research is needed to develop effective preventive and therapeutic control strategies.
Editorial Material
Virology
Daniele Focosi et al.
Summary: This study summarizes the in vitro evidence of efficacy for convalescent plasma, approved vaccines and monoclonal antibodies against various SARS-CoV-2 variants, providing guidance for treating physicians while awaiting real-world clinical efficacy.
Editorial Material
Medicine, General & Internal
Chris Baraniuk
BMJ-BRITISH MEDICAL JOURNAL
(2021)
News Item
Medicine, General & Internal
Elisabeth Mahase
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Letitia Leustean et al.
Summary: Irisin, a novel hormone, has sparked interest in medical research for its potential in treating metabolic disorders like hypothyroidism and polycystic ovary syndrome. It also shows promise in diseases caused by a sedentary lifestyle and may have a role in treating infections like SARSCoV-2. Therapies such as insulin and metformin can influence irisin levels, opening up avenues for future research in optimizing its therapeutic role in endocrine and metabolic diseases.
APPLIED SCIENCES-BASEL
(2021)
Review
Chemistry, Multidisciplinary
Alessia Catalano et al.
Summary: Metal complexes and Schiff bases play important roles in pharmaceutical sciences. Schiff bases are versatile pharmacophores that can form chelating complexes with various metals, exhibiting multiple biological activities.
APPLIED SCIENCES-BASEL
(2021)
Review
Immunology
Nicola Principi et al.
Summary: Vaccination of pregnant women against COVID-19 can protect both the mother and the child, with studies showing no significant difference in the immunogenicity and safety of these vaccines in pregnant women compared to nonpregnant women. Antibodies can be efficiently transferred through the placenta and breastmilk to potentially prevent infection in children. Additional research with larger sample sizes and follow-up studies are needed to better understand the immune response of pregnant women and vaccine efficacy against virus variants.
Review
Health Care Sciences & Services
Vasiliki Romanou et al.
Summary: COVID-19 severity and clinical outcomes are associated with dysregulated antiviral immunity and enhanced systemic inflammation. Corticosteroids like dexamethasone are used to reduce lung inflammation and inflammation-induced lung injury, with wide anti-inflammatory action. However, the optimal timing, dosing, and duration of corticosteroid treatment for COVID-19 patients remain uncertain.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Immunology
Hyunjhung Jhun et al.
Summary: As of September 21, 2021, over 228 million cases of COVID-19 have been reported worldwide, resulting in over 4 million deaths. The predominant circulating variants of concern are alpha, beta, gamma, and delta, originating from different countries like the UK, South Africa, Brazil/Japan, and India, respectively. These variants exhibit unique mutations in the spike gene, which may impact their infectivity and pathogenicity.
Article
Medicine, General & Internal
Vadir Baktash et al.
Summary: The study aimed to assess the importance of vitamin D deficiency in older patients with COVID-19, finding a potential association between vitamin D deficiency and worse outcomes in COVID-19 cases among older adults, without an increased mortality rate.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Engy Elekhnawy et al.
Summary: The recent COVID-19 pandemic has posed challenges to healthcare organizations worldwide, with no proven effective therapeutic agents available against the virus yet. Current research is focusing on repurposing existing drugs to treat COVID-19 cases and exploring potential future therapeutic regimens based on recent molecular and genomic discoveries.
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yiyue Ge et al.
Summary: A drug repositioning framework was developed to identify CVL218 as a potential treatment for COVID-19, with in vitro assays showing its inhibitory effect on SARS-CoV-2 replication and interaction with viral proteins, as well as suppression of inflammatory cytokines relevant to immunopathology induced by the virus.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Biochemical Research Methods
Serena Dotolo et al.
Summary: Drug repurposing involves finding new uses for existing drugs at a lower cost and in a shorter time period. Different computational drug-repurposing strategies, including network-based models, structure-based approaches, and artificial intelligence (AI) approaches, have been applied to COVID-19. Network-based clustering and propagation approaches have been used to identify proteins associated with COVID-19, while structure-based approaches have focused on discovering new applications for existing drugs through interactions with biological targets. AI-based networks, however, require more data before becoming relevant in this context.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Medicine, Research & Experimental
Saeidreza JamaliMoghadamSiahkali et al.
Summary: The study found that there were no significantly better outcomes at discharge in patients with severe COVID-19 who received high-dose intravenous vitamin C (HDIVC) in addition to the main treatment regimen.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Alexandra C. Walls et al.
Review
Pediatrics
Ilaria Liguoro et al.
EUROPEAN JOURNAL OF PEDIATRICS
(2020)
Letter
Public, Environmental & Occupational Health
Mehrdad Zeinalian et al.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2020)
Article
Infectious Diseases
Marissa B. Serafin et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2020)
Review
Virology
Mohammed Uddin et al.
Letter
Cell Biology
Jia Liu et al.
Letter
Biochemistry & Molecular Biology
Ehud Chorin et al.
Article
Biochemistry & Molecular Biology
Olga Abian et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Medicinal
Ruiyuan Cao et al.
ACS INFECTIOUS DISEASES
(2020)
Article
Microbiology
Andrew Rambaut et al.
NATURE MICROBIOLOGY
(2020)
Article
Chemistry, Physical
Kaifu Gao et al.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2020)
Article
Cell Biology
Miriane de Oliveira et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Medicine, General & Internal
Peter Horby et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Letter
Psychiatry
Ramdas Ransing et al.
ASIAN JOURNAL OF PSYCHIATRY
(2020)
Editorial Material
Medicine, General & Internal
Daniel Rubin et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Education, Scientific Disciplines
Diana Serlahwaty et al.
PHARMACY EDUCATION
(2020)
Article
Chemistry, Multidisciplinary
Mostafa A. Mansour et al.
Article
Public, Environmental & Occupational Health
Sandro G. Viveiros Rosa et al.
REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC HEALTH
(2020)
Article
Biochemical Research Methods
James Hadfield et al.
Article
Cell Biology
Roberta Gualdani et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Antonio Rosato et al.
Article
Biochemistry & Molecular Biology
Alessia Fazio et al.
Editorial Material
Infectious Diseases
Yuelong Shu et al.
Article
Chemistry, Medicinal
Domenico Iacopetta et al.
Article
Biochemical Research Methods
Cecilia Pozzi et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
(2012)
Article
Chemistry, Medicinal
C Bruno et al.
