Journal
VIRUSES-BASEL
Volume 14, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/v14030573
Keywords
COVID-19; repositioning; repurposing; pandemic; SARS-CoV-2; vaccines; therapies; drugs; nutraceuticals
Categories
Funding
- PRIN (Progetti di Rilevante Interesse Nazionale) [2017M8R7N9_004, 2020KSY3KL_005]
- MUR, Italy
Ask authors/readers for more resources
The COVID-19 pandemic caused by the SARS-CoV-2 virus poses a severe threat to public health. The search for vaccines has led to the approval of about twenty COVID-19 vaccines, but new genetic mutations and variants continue to emerge, necessitating pharmacological treatments.Various treatments, including antivirals, antibiotics, immunomodulators, vitamins, and drug repositioning, are being used to combat the spread of the virus.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a member of the Coronavirus family which caused the worldwide pandemic of human respiratory illness coronavirus disease 2019 (COVID-19). Presumably emerging at the end of 2019, it poses a severe threat to public health and safety, with a high incidence of transmission, predominately through aerosols and/or direct contact with infected surfaces. In 2020, the search for vaccines began, leading to the obtaining of, to date, about twenty COVID-19 vaccines approved for use in at least one country. However, COVID-19 continues to spread and new genetic mutations and variants have been discovered, requiring pharmacological treatments. The most common therapies for COVID-19 are represented by antiviral and antimalarial agents, antibiotics, immunomodulators, angiotensin II receptor blockers, bradykinin B2 receptor antagonists and corticosteroids. In addition, nutraceuticals, vitamins D and C, omega-3 fatty acids and probiotics are under study. Finally, drug repositioning, which concerns the investigation of existing drugs for new therapeutic target indications, has been widely proposed in the literature for COVID-19 therapies. Considering the importance of this ongoing global public health emergency, this review aims to offer a synthetic up-to-date overview regarding diagnoses, variants and vaccines for COVID-19, with particular attention paid to the adopted treatments.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available