Journal
CANCER LETTERS
Volume 358, Issue 2, Pages 107-114Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.12.047
Keywords
IL-21; Immune response; Cancer
Categories
Funding
- Des Moines University [IOER 05-14-01, IOER 112-3749, IOER 112-3113]
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Interleukin-21 (IL-21), produced predominantly by CD4+ T cells and natural killer T (NKT) cells, is a newly discovered member of the common gamma-chain family of cytokines. It has been implicated in many immunological processes and has been linked to autoimmune diseases, allergies and other inflammatory diseases. In recent years, the role for IL-21 in the pathogenesis of cancer has also been extensively studied. In this review, we will discuss recent advances concerning the role of IL-21 in immunological processes and the pathogenesis of cancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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