Research progress in drug therapy of juvenile idiopathic arthritis

Letter Rheumatology

Effectiveness and safety of ruxolitinib for the treatment of refractory systemic idiopathic juvenile arthritis like associated with interstitial lung disease : a case report

Brigitte Bader-Meunier et al.

ANNALS OF THE RHEUMATIC DISEASES (2022)

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Article Rheumatology

Role of Environment in Pediatric Rheumatic Diseases

Colleen K. Correll

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2022)

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Article Rheumatology

Initiating disease-modifying anti-rheumatic drugs rapidly reduces purchases of analgesic drugs in juvenile idiopathic arthritis

K. Rebane et al.

Summary: Initiation of DMARDs quickly reduces the need for analgesics in JIA patients. NSAIDs are the most commonly purchased analgesics, while purchases of opioid drugs are very low.

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2021)

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Article Dentistry, Oral Surgery & Medicine

Comparing Clinical and Radiological Manifestations of Adolescent Idiopathic Condylar Resorption and Juvenile Idiopathic Arthritis in the Temporomandibular Joint

Dino Alimanovic et al.

Summary: This study compared orofacial manifestations and clinical symptoms at the time of diagnosis in JIA and ICR patients, finding that ICR patients had more severe dentofacial deformities, while JIA patients more commonly reported symptoms such as TMJ pain.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2021)

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Article Rheumatology

Association of novel rare coding variants with juvenile idiopathic arthritis

Xinyi Meng et al.

Summary: This study identified rare coding variants in JIA patients using RNA-seq data, including some reported causal variants. These variants were partially replicated in polyarticular patients and shared common variants with genes associated with autoimmune diseases. Genes related to immune pathways were enriched for rare coding variants and differentially expressed genes.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Article Ophthalmology

Recommendations for the management of childhood juvenile idiopathic arthritis-type chronic anterior uveitis

Justine R. Smith et al.

Summary: The Australian and New Zealand-based uveitis-specialized ophthalmologists have developed 18 consensus statements for managing chronic anterior uveitis in children with JIA, providing regionally applicable advice for ophthalmic care.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2021)

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Article Medicine, Research & Experimental

Hepatoprotective effect of gentiopicroside in combination with leflunomide and/or methotrexate in arthritic rats

Zhijie Wan et al.

Summary: The study demonstrated that gentiopicroside combined with leflunomide (LEF) and/or methotrexate (MTX) can alleviate oxidative stress, reduce inflammation, and improve external symptoms of arthritis in rats by affecting antioxidant and anti-inflammatory pathways.

LIFE SCIENCES (2021)

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Article Rheumatology

Comparative effectiveness and persistence of TNFi and non-TNFi in juvenile idiopathic arthritis: a large paediatric rheumatology centre in the USA

Xiaomeng Yue et al.

Summary: In newly diagnosed JIA patients, TNFi showed better persistence and effectiveness compared to non-TNFi. TNFi had significantly longer persistence than non-TNFi in the first bDMARD course. Additionally, TNFi users had significantly greater reduction in clinical Juvenile Disease Activity Score (cJADAS) at the 6-month follow-up compared to non-TNFi users.

RHEUMATOLOGY (2021)

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Article Rheumatology

Macrophage activation syndrome in systemic lupus erythematosus and systemic-onset juvenile idiopathic arthritis: a retrospective study of similarities and dissimilarities

R. Naveen et al.

Summary: This study compared the clinical and laboratory parameters of MAS in SLE and sJIA, finding that the two diseases are more similar than dissimilar in clinical features and outcome. The criteria meant for MAS in sJIA or SLE-MAS performed equally well in diagnosing both diseases.

RHEUMATOLOGY INTERNATIONAL (2021)

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Review Biochemistry & Molecular Biology

An Update on the Pathogenic Role of Neutrophils in Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still's Disease

Ji-Won Kim et al.

Summary: Neutrophils are crucial immune cells that defend against pathogens through mechanisms such as phagocytosis and formation of neutrophil extracellular traps (NETs). While NETs can kill pathogens, they may also cause toxic effects in hosts and trigger autoimmune responses in susceptible individuals, contributing to various inflammatory autoimmune diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pediatrics

Perinatal risk factors for pediatric onset type 1 diabetes, autoimmune thyroiditis, juvenile idiopathic arthritis, and inflammatory bowel diseases

Laura Raisanen et al.

Summary: The study found that preterm birth is a shared risk factor for autoimmune diseases, especially when combined with postnatal antibiotic treatments. High maternal age is associated with IBD.

EUROPEAN JOURNAL OF PEDIATRICS (2021)

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Article Engineering, Environmental

Copper mixed-triazolate frameworks featuring the thiophene-containing ligand towards enhanced photodegradation of organic contaminants in water

Si Shi et al.

Summary: Copper(I) mixed-triazolate frameworks with thiophene-containing triazole ligands were synthesized and evaluated as photocatalysts for degrading organic pollutants in water. One of the frameworks, CuMtz-1b, showed significantly improved degradation efficiency for various organic contaminants and comparable degradation rates to framework CuTz-1 with H2O2 addition under different light sources. The enhancement in degradation efficiency was attributed to the increased light absorption ability and band structure changes caused by the thiophene-containing triazole ligands incorporated in the framework.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Ophthalmology

Clinical Course and Treatment Paradigms for JIA-related Uveitis and Pars Planitis Uveitis Using Precise Ocular Investigational Methods

Ioannis Papasavvas et al.

Summary: This retrospective study examined the disease course and management modalities of juvenile idiopathic arthritis-related uveitis (JIA uveitis) and intermediate uveitis of the pars planitis type (PP). Results showed that PP patients had a milder disease course with fewer needing systemic treatment, while JIA uveitis patients had more severe disease and frequent complications. The use of precise investigational techniques helped in determining appropriate therapeutic interventions and avoiding unnecessary systemic treatments.

KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE (2021)

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Article Rheumatology

Comparative risk of infections among real-world users of biologics for juvenile idiopathic arthritis: data from the German BIKER registry

Franz Thiele et al.

Summary: In comparison to TNF-alpha inhibitors and Abatacept, IL-1 and IL-6 inhibitors are associated with an increased risk of common and SAE infections. The use of corticosteroids, younger age, cardiac comorbidities, and higher JIA activity were identified as the most significant risk factors for various infectious diseases.

RHEUMATOLOGY INTERNATIONAL (2021)

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Article Pediatrics

Prescribing Patterns and Impact of Factors Associated with Time to Initial Biologic Therapy among Children with Non-systemic Juvenile Idiopathic Arthritis

Xiaomeng Yue et al.

Summary: This study found an increasing trend in using the combination of methotrexate and adalimumab in treating JIA patients. Adalimumab surpassed etanercept as the most frequently prescribed bDMARD. Predictors of earlier initiation of biologic therapy included JIA category enthesitis-related arthritis (ERA), psoriatic arthritis (PsA), number of joints with limited range of motion, and erythrocyte sedimentation rate (ESR).

PEDIATRIC DRUGS (2021)

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Article Medicine, Research & Experimental

Clinical effectiveness and safety of baricitinib for the treatment of juvenile idiopathic arthritis-associated uveitis or chronic anterior antinuclear antibody-positive uveitis: study protocol for an open-label, adalimumab active-controlled phase 3 clinical trial (JUVE-BRIGHT)

Athimalaipet Ramanan et al.

Summary: This study represents the first pediatric clinical trial to evaluate the clinical efficacy and safety of a JAK inhibitor in JIA-uveitis or chronic ANA-positive uveitis. A novel Bayesian design is being used to assess the effectiveness of baricitinib, with an adalimumab reference arm, in this small patient population with unmet medical needs.

TRIALS (2021)

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Article Multidisciplinary Sciences

Acute monoarthritis in young children: comparing the characteristics of patients with juvenile idiopathic arthritis versus septic and undifferentiated arthritis

Marion Thomas et al.

Summary: Acute arthritis is a common reason for pediatric emergency ward visits, which can be caused by juvenile idiopathic arthritis, septic, or undetermined reasons. In young children, septic arthritis is mainly caused by Kingella kingae, highlighting the importance of accurately distinguishing between different types of arthritis for treatment and follow-up purposes.

SCIENTIFIC REPORTS (2021)

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Article Medicine, General & Internal

Leflunomide-induced delayed onset colitis

Tila Muhammad et al.

Summary: A 73-year-old female presented with watery diarrhoea, which was found to be caused by diverticular disease of the sigmoid colon and collagenous colitis. Treatment involved stopping the potentially causative medication and switching to methotrexate, resulting in a significant improvement in symptoms.

BRITISH JOURNAL OF HOSPITAL MEDICINE (2021)

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Review Cardiac & Cardiovascular Systems

Interleukin-1 and the NLRP3 Inflammasome in Pericardial Disease

Alessandra Vecchie et al.

Summary: Pericarditis is generally a benign disease, but complications and/or recurrences may occur in up to 30% of cases. Recent evidence suggests that the activation of the NLRP3 inflammasome is central in the pathophysiology of pericarditis. Colchicine and IL-1-targeted therapies have been found to effectively reduce acute inflammation and decrease the risk of recurrences.

CURRENT CARDIOLOGY REPORTS (2021)

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Article Immunology

Leflunomide ameliorates experimental autoimmune myasthenia gravis by regulating humoral and cellular immune responses

Huan Huang et al.

Summary: The study found that leflunomide can alleviate the severity of EAMG by regulating humoral immune responses and balancing Th cell subsets, potentially by inhibiting Tfh cells and reducing antibody secretion.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Cell Biology

Potential of E3 Ubiquitin Ligases in Cancer Immunity: Opportunities and Challenges

Peng Ye et al.

Summary: The future of immunotherapy lies in finding new targets and new combination therapy methods to reduce side effects and improve treatment response rate. Ubiquitination plays a crucial role in regulating immune checkpoints and pathways. Drugs targeting E3 ubiquitin ligases have shown beneficial effects in antitumor treatments.

CELLS (2021)

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Article Neurosciences

Sulfasalazine maintains blood-brain barrier integrity and relieves lipopolysaccharide-induced inflammation in hCMEC/D3 cells

Sheng Chang et al.

Summary: The study found that sulfasalazine helps maintain the integrity of the blood-brain barrier, alleviates lipopolysaccharide-induced inflammatory apoptosis, and may be an effective treatment for blood-brain barrier disruption.

NEUROREPORT (2021)

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Article Instruments & Instrumentation

Synergistic and receptor-mediated targeting of arthritic joints via intra-articular injectable smart hydrogels containing leflunomide-loaded lipid nanocarriers

Mariam Zewail et al.

Summary: Intra-articular drug delivery using smart hydrogels loaded with nanoencapsulated drugs shows promising results in treating rheumatoid arthritis by targeting inflamed joints. Experimental evidence demonstrates that HA-coated nanostructured lipid carriers result in faster recovery and better joint healing outcomes.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Immunology

Serum protein signatures differentiate paediatric autoimmune/ inflammatory disorders

Emil Carlsson et al.

Summary: Childhood autoimmune/inflammatory conditions pose a diagnostic and therapeutic challenge due to their rarity and overlapping clinical presentations. Research focused on defining disease-specific cytokine and chemokine profiles to differentiate between Juvenile Idiopathic Arthritis (JIA) and Juvenile-onset Systemic Lupus Erythematosus (jSLE). Analysis of serum samples revealed distinct protein signatures that could serve as diagnostic and monitoring markers for these conditions.

CLINICAL IMMUNOLOGY (2021)

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Letter Pediatrics

Tapering Doses of Methylprednisolone Pulse in the Treatment of Macrophage Activation Syndrome Associated with Systemic Juvenile Idiopathic Arthritis

Sathish Loganathan et al.

INDIAN JOURNAL OF PEDIATRICS (2021)

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Review Biochemistry & Molecular Biology

Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism

Hidetoshi Nara et al.

Summary: Interleukin (IL)-6 is a crucial pro-inflammatory cytokine, also showing different functions as a myokine, including its involvement in lipid metabolism in the liver. While IL-6 plays a role in exacerbating factors in coronavirus disease, its specific functions as a muscle-derived myokine and a pro-inflammatory cytokine still require further investigation to clarify the relationship between the two.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pediatrics

Juvenile idiopathic arthritis in Jordan: single center experience

Raed M. Alzyoud et al.

Summary: This study in Jordan on JIA patients evaluated various clinical and laboratory features, with oligoarticular JIA being the most common subtype. It is suggested that future population-based studies should be conducted to gain a more in-depth understanding of JIA characteristics and patterns.

PEDIATRIC RHEUMATOLOGY (2021)

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Article Pediatrics

Patterns of etanercept use in juvenile idiopathic arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry

Timothy Beukelman et al.

Summary: This study characterizes contemporary patterns of ETN use in the CARRA Registry. Treatment was largely in keeping with American College of Rheumatology guidelines.

PEDIATRIC RHEUMATOLOGY (2021)

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Review Pediatrics

Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches

Lina N. Zaripova et al.

Summary: Juvenile idiopathic arthritis (JIA) is classified into different subtypes based on the number of affected joints, extra-articular manifestations, systemic symptoms, serology and genetic factors; advances have been made in understanding the pathogenesis of JIA, including etiology, histopathology, and treatment options.

PEDIATRIC RHEUMATOLOGY (2021)

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Article Pharmacology & Pharmacy

Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular Dystrophy

Matteo Giovarelli et al.

Summary: Duchenne Muscular Dystrophy (DMD) is a rare genetic disorder characterized by progressive muscle wasting, weakness, and premature death. Research has shown that targeting secondary pathological mechanisms, such as mitochondrial dysfunction, is important in improving therapeutic outcomes. Studies have identified two temporally distinct phases of mitochondrial damage in DMD patients, with potential for promoting mitochondrial regeneration and enhancing energy production through specific medications.

PHARMACOLOGICAL RESEARCH (2021)

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Article Clinical Neurology

The Peculiar Clinical Symptoms and Treatment of Limbic Encephalitis Associated with AMPA Receptor Antibody

Yu Jia et al.

Summary: Diseases related to AMPAR antibodies are rare in autoimmune neurological diseases, with diverse clinical manifestations and complex courses. Immunotherapy is effective in some patients, while others may require a combination of treatments.

EUROPEAN NEUROLOGY (2021)

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Article Ophthalmology

Areas of agreement in the management of childhood non-infectious chronic anterior uveitis in the UK

Ameenat Lola Solebo et al.

BRITISH JOURNAL OF OPHTHALMOLOGY (2020)

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Article Rheumatology

Infectious adverse events in children with Juvenile Idiopathic Arthritis treated with Biological Agents in a real-life setting: Data from the JIRcohorte

Cecile Dumaine et al.

JOINT BONE SPINE (2020)

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Review Rheumatology

Towards therapeutic drug monitoring of TNF inhibitors for children with juvenile idiopathic arthritis: a scoping review

Ruud H. J. Verstegen et al.

RHEUMATOLOGY (2020)

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Article Immunology

Do we need a new classification of juvenile idiopathic arthritis?

Alan M. Rosenberg

CLINICAL IMMUNOLOGY (2020)

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Article Rheumatology

Validation and adaptation of a German screening tool to identify patients at risk of juvenile idiopathic arthritis

Tristan Scheer et al.

RHEUMATOLOGY INTERNATIONAL (2020)

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Article Pediatrics

Infliximab therapy and outcomes in patients with polyarticular juvenile idiopathic arthritis: a single-center study in China

Da-Wei Liu et al.

WORLD JOURNAL OF PEDIATRICS (2020)

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Article Clinical Neurology

Current management of juvenile idiopathic arthritis affecting the craniovertebral junction

Scott C. Seaman et al.

CHILDS NERVOUS SYSTEM (2020)

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Review Immunology

Juvenile idiopathic arthritis-associated uveitis

Ethan S. Sen et al.

CLINICAL IMMUNOLOGY (2020)

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Article Rheumatology

JAK inhibitors in refractory juvenile idiopathic arthritis-associated uveitis

Elisabetta Miserocchi et al.

CLINICAL RHEUMATOLOGY (2020)

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Review Immunology

Microbial orchestra in juvenile idiopathic arthritis: Sounds of disarray?

Miika Arvonen et al.

IMMUNOLOGICAL REVIEWS (2020)

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Review Immunology

Systemic autoinflammatory diseases

Julie Krainer et al.

JOURNAL OF AUTOIMMUNITY (2020)

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Article Rheumatology

Drug reactions in children with rheumatic diseases receiving parenteral therapies: 9 years' experience of a tertiary pediatric rheumatology center

Rahime Koc et al.

RHEUMATOLOGY INTERNATIONAL (2020)

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Article Rheumatology

Quality of life in children suffering from juvenile idiopathic arthritis-associated uveitis

Mario Sestan et al.

RHEUMATOLOGY INTERNATIONAL (2020)

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Review Hematology

Management of myelofibrosis after ruxolitinib failure

Claire N. Harrison et al.

ANNALS OF HEMATOLOGY (2020)

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Article Pharmacology & Pharmacy

New insights into the IL-12 and IL-23: From a molecular basis to clinical application in immune-mediated inflammation and cancers

I-Tsu Chyuan et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Therapeutic effects of combination of platelet lysate and sulfasalazine administration in TNBS-induced colitis in rat

Aliakbar Yousefi-Ahmadipour et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Immunology

IL-21+ CD4+ T helper cells co-expressing IFN-γ and TNF-α accumulate in the joints of antinuclear antibody positive patients with juvenile idiopathic arthritis

Jonas Fischer et al.

CLINICAL IMMUNOLOGY (2020)

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Article Rheumatology

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

Sharon L. Kolasinski et al.

ARTHRITIS & RHEUMATOLOGY (2020)

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Editorial Material Rheumatology

Systemic Treatment for Temporomandibular Joint Arthritis in Juvenile Idiopathic Arthritis

Peter Stoustrup et al.

JOURNAL OF RHEUMATOLOGY (2020)

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Article Pediatrics

Interleukin-1 Blockade in Systemic Juvenile Idiopathic Arthritis

Manel Mejbri et al.

PEDIATRIC DRUGS (2020)

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Article Rheumatology

Translating IL-6 biology into effective treatments

Ernest H. Choy et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

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Editorial Material Ophthalmology

Cataract Risk and Topical Corticosteroids among Children with Juvenile Idiopathic Arthritis-Related Uveitis

Michal Kramer et al.

OPHTHALMOLOGY (2020)

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Review Economics

Health State Utility Values in Juvenile Idiopathic Arthritis: What is the Evidence?

Luiza Raquel Grazziotin et al.

PHARMACOECONOMICS (2020)

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Review Medicine, Research & Experimental

Hydroxychloroquine in rheumatic autoimmune disorders and beyond

Eliise Laura Nirk et al.

EMBO MOLECULAR MEDICINE (2020)

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Article Medicine, General & Internal

Biological disease-modifying antirheumatic drugs in juvenile idiopathic arthritis of polyarticular course, enthesitis-related arthritis, and psoriatic arthritis: a consensus statement

Assunta C. H. Ho et al.

HONG KONG MEDICAL JOURNAL (2020)

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Article Rheumatology

Safety of biological agents in paediatric rheumatic diseases: A real-life multicenter retrospective study using the JIRcohorte database

Natalia Cabrera et al.

JOINT BONE SPINE (2019)

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Article Rheumatology

Use and effectiveness of rituximab in children and young people with juvenile idiopathic arthritis in a cohort study in the United Kingdom

Lianne Kearsley-Fleet et al.

RHEUMATOLOGY (2019)

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Review Ophthalmology

Therapeutic advances in juvenile idiopathic arthritis - associated uveitis

Julie Gueudry et al.

CURRENT OPINION IN OPHTHALMOLOGY (2019)

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Editorial Material Rheumatology

Juvenile Idiopathic Arthritis: An Idea Whose Time Has Gone?

Timothy Beukelman et al.

JOURNAL OF RHEUMATOLOGY (2019)

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Editorial Material Ophthalmology

Drug Costs, Effectiveness, and Kids in the Crossfire: Adalimumab in Juvenile Idiopathic Arthritis-Associated Uveitis

Russell N. Van Gelder

OPHTHALMOLOGY (2019)

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Article Engineering, Biomedical

Linking Joint Impairment and Gait Biomechanics in Patients with Juvenile Idiopathic Arthritis

Erica Montefiori et al.

ANNALS OF BIOMEDICAL ENGINEERING (2019)

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Article Pediatrics

Cyclosporine in Resistant Systemic Arthritis - A Cheaper Alternative to Biologics

Priyankar Pal et al.

INDIAN JOURNAL OF PEDIATRICS (2019)

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Article Pediatrics

Tofacitinib Treatment of Refractory Systemic Juvenile Idiopathic Arthritis

Zhixiang Huang et al.

PEDIATRICS (2019)

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Article Rheumatology

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis

Sarah Ringold et al.

ARTHRITIS CARE & RESEARCH (2019)

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Article Rheumatology

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis

Sheila T. Angeles-Han et al.

ARTHRITIS & RHEUMATOLOGY (2019)

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Letter Rheumatology

Testing the Model for Predicting Effectiveness of Anakinra in Systemic Juvenile Idiopathic Arthritis

Seza Ozen et al.

JOURNAL OF RHEUMATOLOGY (2019)

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Editorial Material Rheumatology

Predicting Remission Remains a Challenge in Patients with Juvenile Idiopathic Arthritis

Stephanie J. W. Shoop-Worrall et al.

JOURNAL OF RHEUMATOLOGY (2019)

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Article Rheumatology

Leflunomide treatment in juvenile idiopathic arthritis

Nuray Aktay Ayaz et al.

RHEUMATOLOGY INTERNATIONAL (2019)

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Article Rheumatology

Immunome perturbation is present in patients with juvenile idiopathic arthritis who are in remission and will relapse upon anti-TNFα withdrawal

Jing Yao Leong et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

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Article Pediatrics

Reduction in the utilization of prednisone or methotrexate in Canadian claims data following initiation of etanercept in pediatric patients with juvenile idiopathic arthritis

Majed Khraishi et al.

PEDIATRIC RHEUMATOLOGY (2019)

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Review Health Care Sciences & Services

Clinical evaluation of the safety, efficacy and tolerability of sarilumab in the treatment of moderate to severe rheumatoid arthritis

Eleftherios Pelechas et al.

THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2019)

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Review Immunology

Systematic Review of Safety and Efficacy of Rituximab in Treating Immune-Mediated Disorders

Celine Kaegi et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Ophthalmology

Adalimumab in Juvenile Idiopathic Arthritis-Associated Uveitis: 5-Year Follow-up of the Bristol Participants of the SYCAMORE Trial

Sarah Horton et al.

AMERICAN JOURNAL OF OPHTHALMOLOGY (2019)

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Review Pharmacology & Pharmacy

Biological and synthetic target DMARDs in psoriatic arthritis

Ettore Silvagni et al.

PHARMACOLOGICAL RESEARCH (2019)

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Article Pediatrics

Health-related quality of life during early aggressive treatment in patients with polyarticular juvenile idiopathic arthritis: results from randomized controlled trial

Maarit Tarkiainen et al.

PEDIATRIC RHEUMATOLOGY (2019)

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Article Medicine, General & Internal

Tocilizumab for juvenile idiopathic arthritis: a single-center case series

Fatma Yazilitas et al.

SAO PAULO MEDICAL JOURNAL (2019)

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Review Immunology

Autoantibodies in the Pathogenesis, Diagnosis, and Prognosis of Juvenile Idiopathic Arthritis

Shawn A. Mahmud et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

Targeting Tregs in Juvenile Idiopathic Arthritis and Juvenile Dermatomyositis-Insights From Other Diseases

Romy E. Hoeppli et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Rheumatology

Etanercept treatment for extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, or psoriatic arthritis: 6-year efficacy and safety data from an open-label trial

Ivan Foeldvari et al.

ARTHRITIS RESEARCH & THERAPY (2019)

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Article Rheumatology

Disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era

Gabriella Giancane et al.

ARTHRITIS RESEARCH & THERAPY (2019)

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Article Medicine, General & Internal

Severe acute ocular hypertension following pulsed methylprednisolone for juvenile idiopathic arthritis

Andrew Beverstock et al.

BMJ CASE REPORTS (2019)

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Review Rheumatology

Update upon efficacy and safety of etanercept for the treatment of spondyloarthritis and juvenile idiopathic arthritis

Giuseppe Murdaca et al.

MODERN RHEUMATOLOGY (2018)

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Article Oncology

CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer

Eun Hye Kim et al.

CANCER LETTERS (2018)

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Review Rheumatology

Systemic juvenile idiopathic arthritis and macrophage activation syndrome: update on pathogenesis and treatment

Shima Yasin et al.

CURRENT OPINION IN RHEUMATOLOGY (2018)

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Review Pharmacology & Pharmacy

Sarilumab: A Review in Moderate to Severe Rheumatoid Arthritis

Yvette N. Lamb et al.

DRUGS (2018)

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Article Pharmacology & Pharmacy

Anakinra for the treatment of rheumatoid arthritis: a safety evaluation

Julio Ramirez et al.

EXPERT OPINION ON DRUG SAFETY (2018)

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Article Hematology

Successful treatment of rituximab- and steroid-resistant nephrotic syndrome with leukocytapheresis

Maiko Takakura et al.

JOURNAL OF CLINICAL APHERESIS (2018)

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Article Rheumatology

Longterm Safety and Efficacy of Adalimumab and Infliximab for Uveitis Associated with Juvenile Idiopathic Arthritis

Vanessa Cecchin et al.

JOURNAL OF RHEUMATOLOGY (2018)

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Article Rheumatology

Five successful pregnancies with antenatal anakinra exposure

Chelsey J. F. Smith et al.

RHEUMATOLOGY (2018)

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Article Rheumatology

Validation of Classification Criteria of Macrophage Activation Syndrome in Japanese Patients With Systemic Juvenile Idiopathic Arthritis

Masaki Shimizu et al.

ARTHRITIS CARE & RESEARCH (2018)

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Article Rheumatology

Clinical Characteristics and Factors Associated With Disability and Impaired Quality of Life in Children With Juvenile Systemic Sclerosis: Results From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry

Brandi E. Stevens et al.

ARTHRITIS CARE & RESEARCH (2018)

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Article Cell Biology

Givinostat reduces adverse cardiac remodeling through regulating fibroblasts activation

Marika Milan et al.

CELL DEATH & DISEASE (2018)

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Article Immunology

T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis

Ian D. Ferguson et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Recent advances in our understanding of the pathogenesis of juvenile idiopathic arthritis and their potential clinical implications

Jing Yao Leong et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2018)

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Review Biochemistry & Molecular Biology

The Two-Faced Cytokine IL-6 in Host Defense and Diseases

Masashi Narazaki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Rheumatology

Hydroxychloroquine retinopathy - implications of research advances for rheumatology care

April Jorge et al.

NATURE REVIEWS RHEUMATOLOGY (2018)

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Review Rheumatology

A Review of Recent Advances Using Tocilizumab in the Treatment of Rheumatic Diseases

Andrea Rubbert-Roth et al.

RHEUMATOLOGY AND THERAPY (2018)

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Article Rheumatology

Subcutaneous golimumab for children with active polyarticular-course juvenile idiopathic arthritis: results of a multicentre, double-blind, randomised-withdrawal trial

Hermine I. Brunner et al.

ANNALS OF THE RHEUMATIC DISEASES (2018)

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Article Rheumatology

A phase II trial protocol of Tocilizumab in anti-TNF refractory patients with JIA-associated uveitis (the APTITUDE trial)

Athimalaipet Ramanan et al.

BMC RHEUMATOLOGY (2018)

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Review Pharmacology & Pharmacy

Hydroxychloroquine in systemic lupus erythematosus (SLE)

C. Ponticelli et al.

EXPERT OPINION ON DRUG SAFETY (2017)

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Article Medicine, General & Internal

Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis

Peter C. Taylor et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Pediatrics

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