Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 28, Issue 11, Pages 1184-1186Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v28.i11.1184
Keywords
Gastroesophageal reflux disease; Xiaochaihu decoction; New treatment; Traditional Chinese medicine; Modified Xiaochaihu decoction; Chronic disease
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Funding
- Scientific Research Project of Zhejiang TCM Science and Technology Programme [2020ZB067, 2020ZT001, 2021ZQ031]
- National Natural Science Foundation of China [81503522, 82104862]
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A well-designed study by Li et al showed that modified Xiaochaihu decoction (MXD) may be an alternative therapy for GERD beyond proton pump inhibitors (PPIs). However, the lack of records of side effects and rescue medication was a limitation, and further observation is needed for long-term GERD rehabilitation with MXD therapy.
Gastroesophageal reflux disease (GERD) has a high prevalence worldwide. Li et al performed a well-designed study on the efficacy of modified Xiaochaihu decoction (MXD) for GERD, which showed that MXD is an optional therapy for GERD beyond proton pump inhibitors (PPIs). The herbal granule administration mode minimized the bias from traditional herbal formula in clinical trials. One limitation of that study was that it lacked records of side effects and rescue medication. As a chronic disease with recurrent symptoms, GERD rehabilitation requires prolonged observation of the clinical course with MXD therapy.
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