Journal
CANCER JOURNAL
Volume 21, Issue 6, Pages 486-491Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PPO.0000000000000156
Keywords
Adoptive transfer therapy; antitumor functions; natural killer (NK) cells; prospective therapeutic enhancements; tumor microenvironment
Categories
Funding
- NCI NIH HHS [R35 CA197292, P01 CA111412, P30 CA077598, P01 CA065493] Funding Source: Medline
- NHLBI NIH HHS [T32 HL007062] Funding Source: Medline
Ask authors/readers for more resources
Natural killer (NK) cells constitute an important component of the initial immunological response against transformed cells. However, chronic exposure to the tumor microenvironment can fundamentally alter the ability of NK cells to sufficiently control tumor progression. Thus, the adoptive transfer of healthy, functional NK cells as an interventional therapy has been an area of great interest for improving patient outcomes. Recent developments in the field have provided a better understanding of what makes the NK compartment effective against malignant cells. Moreover, there are now multiple potential sources of NK cell products for infusion as well as techniques to manipulate these cells to enhance their antitumor functions. This review explores the advantages and disadvantages of various sources of NK cells as well as prospective therapeutic enhancements to adoptively transferred NK cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available