Journal
VIRUS RESEARCH
Volume 313, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2022.198739
Keywords
Cattle; Zoonoses; pan-PCR; Metagenomics; RNA virus; Uganda
Categories
Funding
- Swedish Research Council
- College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda [2016-05705]
- Australian Research Council Discovery Early Career Award Fellowship [DE200100977]
- Australian Research Council [DE200100977] Funding Source: Australian Research Council
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The risk of novel zoonotic diseases emerging in animals and humans in Uganda is high due to its geographical location and high biodiversity. A study identified and characterized 8 viral species from cattle blood samples, including highly divergent ones. This suggests that cattle may be reservoir hosts for novel viruses with the potential to cause zoonotic diseases, posing serious public health implications.
The risk for the emergence of novel viral zoonotic diseases in animals and humans in Uganda is high given its geographical location with high biodiversity. We aimed to identify and characterize viruses in 175 blood samples from cattle selected in Uganda using molecular approaches. We identified 8 viral species belonging to 4 families (Flaviviridae, Peribunyaviridae, Reoviridae and Rhabdoviridae) and 6 genera (Hepacivirus, Pestivirus, Orthobunya-virus, Coltivirus, Dinovernavirus and Ephemerovirus). Four viruses were highly divergent and tetantively named Zikole virus (Family: Flaviviridae), Zeboroti virus (Family: Reoviridae), Zebtine virus (Family: Rhabdoviridae) and Kokolu virus (Family: Rhabdoviridae). In addition, Bovine Hepacivirus, Obodhiang virus, Aedes pseudoscutellaris reovirus and Schmallenberg virus were identified for the first time in Ugandan cattle. We report 8 viral species belonging to 4 viral families including divergent ones in the blood of cattle in Uganda. Hence, cattle may be reservoir hosts for likely emergence of novel viruses with pathogenic potential to cause zoonotic diseases in different species with serious public health implications.
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